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Gene Review

Dio2  -  deiodinase, iodothyronine, type II

Mus musculus

Synonyms: 5DII, AI324267, DIOII, Type 2 DI, Type II iodothyronine deiodinase, ...
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Disease relevance of Dio2


High impact information on Dio2


  1. The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue. de Jesus, L.A., Carvalho, S.D., Ribeiro, M.O., Schneider, M., Kim, S.W., Harney, J.W., Larsen, P.R., Bianco, A.C. J. Clin. Invest. (2001) [Pubmed]
  2. Mice with targeted disruption of the Dio2 gene have cold-induced overexpression of the uncoupling protein 1 gene but fail to increase brown adipose tissue lipogenesis and adaptive thermogenesis. Christoffolete, M.A., Linardi, C.C., de Jesus, L., Ebina, K.N., Carvalho, S.D., Ribeiro, M.O., Rabelo, R., Curcio, C., Martins, L., Kimura, E.T., Bianco, A.C. Diabetes (2004) [Pubmed]
  3. Methylmercury inhibits type II 5'-deiodinase activity in NB41A3 neuroblastoma cells. Mori, K., Yoshida, K., Tani, J., Hoshikawa, S., Ito, S., Watanabe, C. Toxicol. Lett. (2006) [Pubmed]
  4. Hepatic deiodinase activity is dispensable for the maintenance of normal circulating thyroid hormone levels in mice. Streckfuss, F., Hamann, I., Schomburg, L., Michaelis, M., Sapin, R., Klein, M.O., Köhrle, J., Schweizer, U. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  5. Isolation and characterization of the 5'-upstream and untranslated regions of the mouse type II iodothyronine deiodinase gene. Song, S., Adachi, K., Katsuyama, M., Sorimachi, K., Oka, T. Mol. Cell. Endocrinol. (2000) [Pubmed]
  6. Biochemical and molecular biological evidence for the presence of type II iodothyronine deiodinase in mouse mammary gland. Song, S., Sorimachi, K., Adachi, K., Oka, T. Mol. Cell. Endocrinol. (2000) [Pubmed]
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