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Gene Review:

TBX20 - T-box 20

Gallus gallus

Plageman, T.F. et al., Yamagishi, T. et al., Sakabe, M. et al.

Yamagishi, Nakajima, Nishimatsu, Nohno, Ando, Nakamura,

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High impact information on TBX20

To elucidate upstream signaling pathways that regulate Tbx5 and Tbx20 expression, recombinant bone morphogenetic protein-2 was added to cardiogenic explants from chick embryos [1].
At the earliest stages of heart development, two of these genes, Tbx5 and Tbx20, are co-expressed in the heart-forming region but then become differentially expressed as heart morphogenesis progresses [1].
At later stages, although tbx20 was expressed predominantly in the nascent right ventricle, transcripts of tbx20 were down-regulated in the left ventricle [2].
In situ hybridization showed that tbx20 was expressed in the lateral plate mesoderm and subsequently in the primitive heart tube [2].
T-box transcription factors are involved in the formation of the heart segments: Tbx5 identifies the left ventricle and Tbx20 the right ventricle [3].

References

Differential expression and function of Tbx5 and Tbx20 in cardiac development. Plageman, T.F., Yutzey, K.E. J. Biol. Chem. (2004) [Pubmed]
Expression of tbx20 RNA during chick heart development. Yamagishi, T., Nakajima, Y., Nishimatsu, S., Nohno, T., Ando, K., Nakamura, H. Dev. Dyn. (2004) [Pubmed]
Understanding heart development and congenital heart defects through developmental biology: a segmental approach. Sakabe, M., Matsui, H., Sakata, H., Ando, K., Yamagishi, T., Nakajima, Y. Congenital anomalies. (2005) [Pubmed]

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