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Gene Review

Tbx20  -  T-box 20

Mus musculus

Synonyms: 9430010M06Rik, AL022859, T-box protein 20, T-box transcription factor TBX20, Tbx12
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Disease relevance of Tbx20


High impact information on Tbx20

  • Tbx20 is expressed by migrating branchiomotor/visceromotor (BM/VM) neurons within the hindbrain during neuronal circuit formation [2].
  • Our study suggests that Tbx20 programs a variety of hindbrain motor neurons for migration, independent of directionality, and in facial neurons is a positive regulator of the non-canonical Wnt signaling pathway [2].
  • Loss of Tbx20 results in death of embryos at mid-gestation with grossly abnormal heart morphogenesis [3].
  • Tbx20 could activate promoters/enhancers of several genes in cultured cells, including the Mef2c AHF enhancer and the Nkx2-5 cardiac enhancer [1].
  • Finally, an intermediate knockdown revealed a role for Tbx20 in motoneuron development, specifically in the regulation of the transcription factors Isl2 and Hb9, which are important for terminal differentiation of motoneurons [1].

Biological context of Tbx20

  • We conclude that Tbx20 is positioned at a critical node in transcription factor networks required for heart and motoneuron development where it dose-dependently regulates gene expression [1].
  • To elucidate the function of the T-box transcription factor Tbx20 in mammalian development, we generated a graded loss-of-function series by transgenic RNA interference in entirely embryonic stem cell-derived mouse embryos [1].

Anatomical context of Tbx20

  • In the mouse, Tbx20 is expressed in the cardiac crescent, then in the endocardium and myocardium of the linear and looped heart tube before it is restricted to the atrioventricular canal and outflow tract in the multi-chambered heart [4].
  • Tbx12 is expressed in extraembryonic tissues such as the amnion and allantois [5].

Regulatory relationships of Tbx20

  • Tbx20-null mice exhibit severely hypoplastic hearts and express Tbx2, which is normally restricted to outflow tract and atrioventricular canal, throughout the heart [6].

Other interactions of Tbx20

  • We provide evidence that Tbx2 is a direct target for repression by Tbx20 in developing heart [6].
  • In chamber myocardium, Tbx20 represses Tbx2, preventing repression of Nmyc1 and resulting in relatively high proliferation [6].
  • In this report, we describe the cloning and expression analysis of a novel mouse T-box gene, Tbx20 [7].

Analytical, diagnostic and therapeutic context of Tbx20


  1. Tbx20 dose-dependently regulates transcription factor networks required for mouse heart and motoneuron development. Takeuchi, J.K., Mileikovskaia, M., Koshiba-Takeuchi, K., Heidt, A.B., Mori, A.D., Arruda, E.P., Gertsenstein, M., Georges, R., Davidson, L., Mo, R., Hui, C.C., Henkelman, R.M., Nemer, M., Black, B.L., Nagy, A., Bruneau, B.G. Development (2005) [Pubmed]
  2. T-Box transcription factor Tbx20 regulates a genetic program for cranial motor neuron cell body migration. Song, M.R., Shirasaki, R., Cai, C.L., Ruiz, E.C., Evans, S.M., Lee, S.K., Pfaff, S.L. Development (2006) [Pubmed]
  3. Murine T-box transcription factor Tbx20 acts as a repressor during heart development, and is essential for adult heart integrity, function and adaptation. Stennard, F.A., Costa, M.W., Lai, D., Biben, C., Furtado, M.B., Solloway, M.J., McCulley, D.J., Leimena, C., Preis, J.I., Dunwoodie, S.L., Elliott, D.E., Prall, O.W., Black, B.L., Fatkin, D., Harvey, R.P. Development (2005) [Pubmed]
  4. Tbx20 is essential for cardiac chamber differentiation and repression of Tbx2. Singh, M.K., Christoffels, V.M., Dias, J.M., Trowe, M.O., Petry, M., Schuster-Gossler, K., Bürger, A., Ericson, J., Kispert, A. Development (2005) [Pubmed]
  5. Tbx12, a novel T-box gene, is expressed during early stages of heart and retinal development. Carson, C.T., Kinzler, E.R., Parr, B.A. Mech. Dev. (2000) [Pubmed]
  6. T-box genes coordinate regional rates of proliferation and regional specification during cardiogenesis. Cai, C.L., Zhou, W., Yang, L., Bu, L., Qyang, Y., Zhang, X., Li, X., Rosenfeld, M.G., Chen, J., Evans, S. Development (2005) [Pubmed]
  7. Cloning and expression analysis of the mouse T-box gene tbx20. Kraus, F., Haenig, B., Kispert, A. Mech. Dev. (2001) [Pubmed]
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