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Gene Review

TBX20  -  T-box 20

Homo sapiens

Synonyms: T-box protein 20, T-box transcription factor TBX20
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Disease relevance of TBX20


High impact information on TBX20

  • T-Box transcription factor Tbx20 regulates a genetic program for cranial motor neuron cell body migration [2].
  • Consistent with this proposal, we show that TBX5 and TBX20 can physically interact and map the interaction domains, and we show a cellular interaction for the two proteins in cardiac development, thus providing the first evidence for direct interaction between members of the T-box gene family [3].
  • Tbx20 was expressed in myocardium and endocardium, including high levels in endocardial cushions. cDNAs generated by alternative splicing encode at least four Tbx20 isoforms, and Tbx20a uniquely carried strong transactivation and transrepression domains in its C terminus [4].
  • The TBX20 gene maps to chromosome 7p14-p15 [5].
  • We find that TBX20 is expressed in the fetal heart, eye, and limb, and during embryogenesis in the mouse, Tbx20 is expressed in the developing heart, eye, ventral neural tube, and limbs, indicating a possible role in regulating development of these tissues [5].


  1. Murine T-box transcription factor Tbx20 acts as a repressor during heart development, and is essential for adult heart integrity, function and adaptation. Stennard, F.A., Costa, M.W., Lai, D., Biben, C., Furtado, M.B., Solloway, M.J., McCulley, D.J., Leimena, C., Preis, J.I., Dunwoodie, S.L., Elliott, D.E., Prall, O.W., Black, B.L., Fatkin, D., Harvey, R.P. Development (2005) [Pubmed]
  2. T-Box transcription factor Tbx20 regulates a genetic program for cranial motor neuron cell body migration. Song, M.R., Shirasaki, R., Cai, C.L., Ruiz, E.C., Evans, S.M., Lee, S.K., Pfaff, S.L. Development (2006) [Pubmed]
  3. Tbx5 and Tbx20 act synergistically to control vertebrate heart morphogenesis. Brown, D.D., Martz, S.N., Binder, O., Goetz, S.C., Price, B.M., Smith, J.C., Conlon, F.L. Development (2005) [Pubmed]
  4. Cardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heart. Stennard, F.A., Costa, M.W., Elliott, D.A., Rankin, S., Haast, S.J., Lai, D., McDonald, L.P., Niederreither, K., Dolle, P., Bruneau, B.G., Zorn, A.M., Harvey, R.P. Dev. Biol. (2003) [Pubmed]
  5. Characterization of the human TBX20 gene, a new member of the T-Box gene family closely related to the Drosophila H15 gene. Meins, M., Henderson, D.J., Bhattacharya, S.S., Sowden, J.C. Genomics (2000) [Pubmed]
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