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Gene Review

FZD7  -  frizzled class receptor 7

Homo sapiens

Synonyms: Frizzled-7, Fz-7, FzE3, hFz7
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Disease relevance of FZD7


High impact information on FZD7


Biological context of FZD7

  • The FZD1 and FZD7 genes have been mapped to human chromosome 7q21 and 2q33, respectively [7].
  • Upregulation of FZD7 was associated with reduced phosphorylation of beta-catenin and led to nuclear accumulation in HCC tumors [8].
  • The morphological and phenotype changes induced by FZD7 ectodomain expression in SK-CO-1 cells is thus consistent with the cells undergoing an epithelial-to-mesenchymal-like transition [2].
  • Nucleotide position 153000-152216 of AC136379.2 genome sequence was identified as the evolutionarily conserved promoter region of rat Fzd7 gene, and nucleotide position 2273-3046 of AC069148.6 genome sequence as the evolutionarily conserved promoter region of human FZD7 gene [9].
  • As over-expression of Frizzled-7 leads to activation of the WNT-beta-catenin-TCF pathway, up-regulation of FZD7 in human gastric cancer might play key roles in carcinogenesis through activation of the WNT-beta-catenin-TCF pathway [5].

Anatomical context of FZD7


Associations of FZD7 with chemical compounds

  • FZD1, FZD2, and FZD7 share a common structure consisting of seven transmembrane domains, a cysteine-rich domain in the N-terminal extracellular region, and the C-terminal Ser/Thr-Xxx-Val motif [7].

Regulatory relationships of FZD7


Other interactions of FZD7


Analytical, diagnostic and therapeutic context of FZD7

  • Furthermore, initiation of tumor formation in a xenograft tumor growth assay was attenuated in the FZD7 ectodomain expressing cells [2].


  1. Expression profiles of 10 members of Frizzled gene family in human gastric cancer. Kirikoshi, H., Sekihara, H., Katoh, M. Int. J. Oncol. (2001) [Pubmed]
  2. Frizzled-7 receptor ectodomain expression in a colon cancer cell line induces morphological change and attenuates tumor growth. Vincan, E., Darcy, P.K., Smyth, M.J., Thompson, E.W., Thomas, R.J., Phillips, W.A., Ramsay, R.G. Differentiation (2005) [Pubmed]
  3. Comparative integromics on FZD7 orthologs: Conserved binding sites for PU.1, SP1, CCAAT-box and TCF/LEF/SOX transcription factors within 5'-promoter region of mammalian FZD7 orthologs. Katoh, M., Katoh, M. Int. J. Mol. Med. (2007) [Pubmed]
  4. Functional consequences of frizzled-7 receptor overexpression in human hepatocellular carcinoma. Merle, P., de la Monte, S., Kim, M., Herrmann, M., Tanaka, S., Von Dem Bussche, A., Kew, M.C., Trepo, C., Wands, J.R. Gastroenterology (2004) [Pubmed]
  5. Up-regulation of Frizzled-7 (FZD7) in human gastric cancer. Kirikoshi, H., Sekihara, H., Katoh, M. Int. J. Oncol. (2001) [Pubmed]
  6. Wnt11 controls cell contact persistence by local accumulation of Frizzled 7 at the plasma membrane. Witzel, S., Zimyanin, V., Carreira-Barbosa, F., Tada, M., Heisenberg, C.P. J. Cell Biol. (2006) [Pubmed]
  7. Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7. Sagara, N., Toda, G., Hirai, M., Terada, M., Katoh, M. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  8. Oncogenic role of the frizzled-7/beta-catenin pathway in hepatocellular carcinoma. Merle, P., Kim, M., Herrmann, M., Gupte, A., Lefrançois, L., Califano, S., Trépo, C., Tanaka, S., Vitvitski, L., de la Monte, S., Wands, J.R. J. Hepatol. (2005) [Pubmed]
  9. Comparative genomics on Fzd7 orthologs. Katoh, M., Katoh, M. Int. J. Mol. Med. (2005) [Pubmed]
  10. A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals. Tanaka, S., Akiyoshi, T., Mori, M., Wands, J.R., Sugimachi, K. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  11. Molecular cloning and characterization of human Frizzled-5 gene on chromosome 2q33.3-q34 region. Saitoh, T., Hirai, M., Katoh, M. Int. J. Oncol. (2001) [Pubmed]
  12. Interaction of Frizzled 7 and Dishevelled in Xenopus. Medina, A., Steinbeisser, H. Dev. Dyn. (2000) [Pubmed]
  13. Demineralized bone alters expression of Wnt network components during chondroinduction of post-natal fibroblasts. Yates, K.E. Osteoarthr. Cartil. (2004) [Pubmed]
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