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Gene Review

Klp59C  -  Kinesin-like protein at 59C

Drosophila melanogaster

Synonyms: CG3219, DmCG3219, DmKLP59C, DmKlp59C, Dmel\CG3219, ...
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High impact information on Klp59C

  • Analyses of microtubule dynamics in S2 cells depleted of these proteins indicate that both proteins stimulate depolymerization, but alter distinct parameters of dynamic instability; KLP10A stimulates catastrophe (a switch from growth to shrinkage) whereas KLP59C suppresses rescue (a switch from shrinkage to growth) [1].
  • One of them, KLP59C, is required to depolymerize kinetochore microtubules at their kinetochore-associated plus ends, thereby contributing to chromatid motility through a Pac-Man-based mechanism [2].

Biological context of Klp59C


Other interactions of Klp59C


  1. Functionally distinct kinesin-13 family members cooperate to regulate microtubule dynamics during interphase. Mennella, V., Rogers, G.C., Rogers, S.L., Buster, D.W., Vale, R.D., Sharp, D.J. Nat. Cell Biol. (2005) [Pubmed]
  2. Two mitotic kinesins cooperate to drive sister chromatid separation during anaphase. Rogers, G.C., Rogers, S.L., Schwimmer, T.A., Ems-McClung, S.C., Walczak, C.E., Vale, R.D., Scholey, J.M., Sharp, D.J. Nature (2004) [Pubmed]
  3. KLP10A and KLP59C: the dynamic duo of microtubule depolymerization. Sharp, D.J., Mennella, V., Buster, D.W. Cell Cycle (2005) [Pubmed]
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