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Gene Review:

KCNJ14 - potassium channel, inwardly rectifying...

Homo sapiens

Synonyms: ATP-sensitive inward rectifier potassium channel 14, IRK-4, IRK4, Inward rectifier K(+) channel Kir2.4, KIR2.4, ...

Töpert, C. et al., Hughes, B.A. et al., Mömke, S. et al., Töpert, C. et al., Liu, Y. et al.

Hughes, Kumar, Yuan, Swaminathan, Yan, Sharma, Plumley, Yang-Feng, Swaroop, Liu, Liu, Heath, Meyers, Krafte, Wagoner, Silvia, Yu, Curran,

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High impact information on KCNJ14

Heterologous expression of Kir2.4 in Xenopus oocytes and mammalian cells gives rise to low-conductance channels (15 pS), with an affinity to the channel blockers Ba2+ (Ki = 390 microM) and Cs+ (Ki = 8.06 mM) 30-50-fold lower than in other Kir channels [1].
Kir2.4: a novel K+ inward rectifier channel associated with motoneurons of cranial nerve nuclei [1].
AA had no effect on the currents flowing through Kir2.1, Kir2.2, or Kir2.4 channels [2].
Somatic hybridization analysis and dual-color in situ hybridization to metaphase chromosomes mapped Kir2.4 to human chromosome 19 q13.1-q13 [3].
Cloning, structure and assignment to chromosome 19q13 of the human Kir2.4 inwardly rectifying potassium channel gene (KCNJ14) [4].

Other interactions of KCNJ14

The location of KCNJ14 and SLC27A5 flanking the RH map on BTA18q25-26 has been confirmed by fluorescence in situ hybridization [5].

Analytical, diagnostic and therapeutic context of KCNJ14

Low Ba2+ sensitivity allows dissection of Kir2.4 currents from other Kir conductances in hypoglossal motoneurons (HMs) in rat brainstem slices [1].

References

Kir2.4: a novel K+ inward rectifier channel associated with motoneurons of cranial nerve nuclei. Töpert, C., Döring, F., Wischmeyer, E., Karschin, C., Brockhaus, J., Ballanyi, K., Derst, C., Karschin, A. J. Neurosci. (1998) [Pubmed]
Direct activation of an inwardly rectifying potassium channel by arachidonic acid. Liu, Y., Liu, D., Heath, L., Meyers, D.M., Krafte, D.S., Wagoner, P.K., Silvia, C.P., Yu, W., Curran, M.E. Mol. Pharmacol. (2001) [Pubmed]
Cloning and functional expression of human retinal kir2.4, a pH-sensitive inwardly rectifying K(+) channel. Hughes, B.A., Kumar, G., Yuan, Y., Swaminathan, A., Yan, D., Sharma, A., Plumley, L., Yang-Feng, T.L., Swaroop, A. Am. J. Physiol., Cell Physiol. (2000) [Pubmed]
Cloning, structure and assignment to chromosome 19q13 of the human Kir2.4 inwardly rectifying potassium channel gene (KCNJ14). Töpert, C., Döring, F., Derst, C., Daut, J., Grzeschik, K.H., Karschin, A. Mamm. Genome (2000) [Pubmed]
A refined radiation hybrid map of the telomeric region of bovine chromosome 18q25-q26 compared with human chromosome 19q13. Mömke, S., Kuiper, H., Spötter, A., Drögemüller, C., Distl, O. Anim. Genet. (2005) [Pubmed]

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