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Gene Review

SIX3  -  SIX homeobox 3

Gallus gallus

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High impact information on SIX3

  • During chick eye morphogenesis, the homeobox gene Six3 is expressed in a subset of periocular mesenchymal cells and in differentiating anterior segment tissues [1].
  • Histological and molecular marker analyses demonstrate that Six3 misexpression disrupts the integrity of the corneal endothelium and the expression of extracellular matrix components critical for corneal transparency [1].
  • Retrovirus-mediated misexpression of Six3 causes eye anterior segment malformation, including corneal protrusion and opacification, ciliary body and iris hypoplasia, and trabecular meshwork dysgenesis [1].


  1. The homeobox gene Six3 is a potential regulator of anterior segment formation in the chick eye. Hsieh, Y.W., Zhang, X.M., Lin, E., Oliver, G., Yang, X.J. Dev. Biol. (2002) [Pubmed]
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