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Gene Review

six3a  -  SIX homeobox 3a

Danio rerio

Synonyms: SO:0000704, six3, six3.1, wu:fc10a08
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Disease relevance of six3a


High impact information on six3a

  • Our results indicate that reduction in Brg1 expression leads to the expansion of the forebrain-specific transcription factor, six3, and marked reduction in expression of the mid/hind-brain boundary and hind-brain genes, engrailed2 and krox20, respectively [2].
  • Furthermore, an enhancement of six3.1 transcription by Pax6.1 was observed by co-injection experiments [1].
  • We studied the 5(') flanking region of six3.1 and showed that separate enhancing elements are required for expression at different stages of eye development [1].


  1. Retinal expression of zebrafish six3.1 and its regulation by Pax6. Wargelius, A., Seo, H.C., Austbø, L., Fjose, A. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  2. Critical role of Brg1 member of the SWI/SNF chromatin remodeling complex during neurogenesis and neural crest induction in zebrafish. Eroglu, B., Wang, G., Tu, N., Sun, X., Mivechi, N.F. Dev. Dyn. (2006) [Pubmed]
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