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Gene Review:

Nurf-38 - Nucleosome remodeling factor - 38kD

Drosophila melanogaster

Synonyms: 38, CG4634, Dmel\CG4634, Inorganic pyrophosphatase, N38, ...

Gdula, D.A. et al., Stronach, B.E. et al., Hiatt, V. et al.

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High impact information on Nurf-38

Inhibition of the pyrophosphatase activity of NURF with sodium fluoride has no significant effect on chromatin remodeling, indicating that these two activities may be biochemically uncoupled [1].
Alternatively, because accumulation of unhydrolyzed pyrophosphate during nucleotide incorporation inhibits polymerization, NURF may also have been adapted to deliver pyrophosphatase to chromatin to assist in replication or transcription by efficient removal of the inhibitory metabolite [1].
The role of the p38 pathway in generation of axial polarity during oogenesis has been inferred from phenotypic analysis of mutations in the Drosophila homolog of DMKK3 [2].
The stimulatory factor is separated from inorganic pyrophosphatase activity by DEAE-cellulose chromatography and from aminoacyl-tRNA synthetase activity by trichloroacetic acid precipitation [3].

Analytical, diagnostic and therapeutic context of Nurf-38

In addition to their requirement for normal development, cell culture and genetic investigations point to a role for both the JNK and p38 pathways in regulation of the immune response in the fly [2].

References

Inorganic pyrophosphatase is a component of the Drosophila nucleosome remodeling factor complex. Gdula, D.A., Sandaltzopoulos, R., Tsukiyama, T., Ossipow, V., Wu, C. Genes Dev. (1998) [Pubmed]
Stress signaling in Drosophila. Stronach, B.E., Perrimon, N. Oncogene (1999) [Pubmed]
Stimulatory factor for tRNA aminoacylation: possible product of modifier genes in Drosophila melanogaster. Hiatt, V., Hillman, R. Biochim. Biophys. Acta (1980) [Pubmed]

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