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Gene Review

Orc4  -  Origin recognition complex subunit 4

Drosophila melanogaster

Synonyms: CG2917, DmORC4, Dmel\CG2917, ORC, ORC4, ...
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High impact information on Orc4

  • We show that Spotted-dick/Pita functions as a transcription factor and that, in cultured S2 cells, it is an activator of expression of some 30 genes that include the Orc4 gene, required for initiation of DNA replication [1].
  • Spotted-dick, a zinc-finger protein of Drosophila required for expression of Orc4 and S phase [1].
  • We report here that the smallest Drosophila ORC subunit, Orc6, is a DNA binding protein that is necessary for the DNA binding and DNA replication functions of ORC [2].
  • We propose that the abnormal subcellular distribution and segregation of ORC proteins in AD might compromise their physiological function in gene silencing and plasticity [3].
  • ORC subunits might, thus, provide a direct molecular link between synaptic plasticity, DNA replication and cell death [3].

Biological context of Orc4

  • The ORC is a critical "guard" of DNA replication and point of convergence of numerous functionally redundant signaling pathways involved in cell cycle progression and transcriptional silencing of apoptotic programmes [3].
  • ORC subunits in the mammalian brain and their homologes in Drosophila, however, have further been implicated in the regulation of structural neuronal plasticity and cognitive function [3].


  1. Spotted-dick, a zinc-finger protein of Drosophila required for expression of Orc4 and S phase. Page, A.R., Kovacs, A., Deak, P., Torok, T., Kiss, I., Dario, P., Bastos, C., Batista, P., Gomes, R., Ohkura, H., Russell, S., Glover, D.M. EMBO J. (2005) [Pubmed]
  2. Role of the Orc6 Protein in Origin Recognition Complex-Dependent DNA Binding and Replication in Drosophila melanogaster. Balasov, M., Huijbregts, R.P., Chesnokov, I. Mol. Cell. Biol. (2007) [Pubmed]
  3. Linking cell-cycle dysfunction in Alzheimer's disease to a failure of synaptic plasticity. Arendt, T., Brückner, M.K. Biochim. Biophys. Acta (2007) [Pubmed]
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