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Gene Review

ORC4  -  origin recognition complex, subunit 4

Homo sapiens

Synonyms: HsORC4, ORC4L, ORC4P, Orc4p, Origin recognition complex subunit 4
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High impact information on ORC4L

  • Green fluorescent protein-tagged ORC1 associated with chromatin throughout mitosis in living cells and co-localized with ORC4 in metaphase spreads [1].
  • ORC1, ORC4 and Cdc6 were stable (T1/2 >2 h) and associated with a chromatin-containing fraction throughout the cell cycle [1].
  • These studies indicate that the ATP-binding motifs of Orc1, Orc4, and Orc5 are all essential for the replication activity associated with HsORC [2].
  • HsORC4 mRNA expression and protein levels remain constant through the cell cycle [3].
  • HsORC4 has a putative nucleotide triphosphate binding motif that is not seen in ScORC4 [3].

Biological context of ORC4L


Anatomical context of ORC4L

  • Cellular extraction revealed that the proportion of ORC2 and ORC4 subunits bound to chromatin was similar in all three cell lines throughout the cell-cycle [4].


  1. Stability, chromatin association and functional activity of mammalian pre-replication complex proteins during the cell cycle. Okuno, Y., McNairn, A.J., den Elzen, N., Pines, J., Gilbert, D.M. EMBO J. (2001) [Pubmed]
  2. Studies of the properties of human origin recognition complex and its Walker A motif mutants. Giordano-Coltart, J., Ying, C.Y., Gautier, J., Hurwitz, J. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  3. Identification of HsORC4, a member of the human origin of replication recognition complex. Quintana, D.G., Hou, Z.h., Thome, K.C., Hendricks, M., Saha, P., Dutta, A. J. Biol. Chem. (1997) [Pubmed]
  4. Overexpression of ORC subunits and increased ORC-chromatin association in transformed mammalian cells. McNairn, A.J., Gilbert, D.M. J. Cell. Biochem. (2005) [Pubmed]
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