High impact information on klar

• HKB controls polarized cell shape change and apical membrane growth during salivary cell invagination via two downstream target genes, crumbs (crb), a determinant of the apical membrane, and klarsicht (klar), which mediates microtubule-dependent organelle transport [1].
• In ovaries, Klar is present on the nuclear envelope, a localization that requires the C-terminal KASH domain [2].
• The Klarsicht/lamin interaction provides a framework for understanding the mechanistic basis of human laminopathies [3].
• Here, we show that Klarsicht is required for connecting the microtubule organizing center (MTOC) to the nucleus [3].
• The functions of Klarsicht and nuclear lamin in developmentally regulated nuclear migrations of photoreceptor cells in the Drosophila eye [3].

Biological context of klar

• Epitope-tagged Klarsicht expressed in the eye from a transgene was perinuclear [4].

Anatomical context of klar

• We propose that nuclear migration requires linkage of the MTOC to the nucleus through an interaction between microtubules, Klarsicht, and lamin [3].
• Vesicle transport: klarsicht clears up the matter [5].
• Syne-1, a dystrophin- and Klarsicht-related protein associated with synaptic nuclei at the neuromuscular junction [6].

Other interactions of klar

• In invaginating salivary cells, crb and klar mediate growth and delivery of apical membrane, respectively, thus regulating the size and shape of the salivary tube [1].

References