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Gene Review

klar  -  klarsicht

Drosophila melanogaster

Synonyms: CG17046, Dmel\CG17046, Klar, kls, marb
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High impact information on klar

  • HKB controls polarized cell shape change and apical membrane growth during salivary cell invagination via two downstream target genes, crumbs (crb), a determinant of the apical membrane, and klarsicht (klar), which mediates microtubule-dependent organelle transport [1].
  • In ovaries, Klar is present on the nuclear envelope, a localization that requires the C-terminal KASH domain [2].
  • The Klarsicht/lamin interaction provides a framework for understanding the mechanistic basis of human laminopathies [3].
  • Here, we show that Klarsicht is required for connecting the microtubule organizing center (MTOC) to the nucleus [3].
  • The functions of Klarsicht and nuclear lamin in developmentally regulated nuclear migrations of photoreceptor cells in the Drosophila eye [3].

Biological context of klar


Anatomical context of klar


Other interactions of klar

  • In invaginating salivary cells, crb and klar mediate growth and delivery of apical membrane, respectively, thus regulating the size and shape of the salivary tube [1].


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