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KRT6A  -  keratin 6A, type II

Homo sapiens

Synonyms: CK-6A, CK-6D, CK6A, CK6C, CK6D, ...
 
 
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Disease relevance of KRT6A

 

High impact information on KRT6A

 

Analytical, diagnostic and therapeutic context of KRT6A

  • Here, we describe a mutation detection strategy where the entire KRT6A gene, approximately 7 kb, is specifically amplified by long-range PCR [5].
  • Within the prostate organ culture model the increase of cytokeratin 6a-expressing cells significantly correlated with increased proliferation index (r = 0.7616, p = 0.0467) [3].

References

  1. Gastric cancers overexpress S100A calcium-binding proteins. El-Rifai, W., Moskaluk, C.A., Abdrabbo, M.K., Harper, J., Yoshida, C., Riggins, G.J., Frierson, H.F., Powell, S.M. Cancer Res. (2002) [Pubmed]
  2. A reporter transgene based on a human keratin 6 gene promoter is specifically expressed in the periderm of mouse embryos. Mazzalupo, S., Coulombe, P.A. Mech. Dev. (2001) [Pubmed]
  3. Identification of a stem cell candidate in the normal human prostate gland. Schmelz, M., Moll, R., Hesse, U., Prasad, A.R., Gandolfi, J.A., Hasan, S.R., Bartholdi, M., Cress, A.E. Eur. J. Cell Biol. (2005) [Pubmed]
  4. A severe case of pachyonychia congenita type I due to a novel proline mutation in keratin 6a. García-Rio, I., Peñas, P.F., García-Díez, A., McLean, W.H., Smith, F.J. Br. J. Dermatol. (2005) [Pubmed]
  5. A mutation detection strategy for the human keratin 6A gene and novel missense mutations in two cases of pachyonychia congenita type 1. Smith, F.J., McKenna, K.E., Irvine, A.D., Bingham, E.A., Coleman, C.M., Uitto, J., McLean, W.H. Exp. Dermatol. (1999) [Pubmed]
  6. SiRNA-Mediated Selective Inhibition of Mutant Keratin mRNAs Responsible for the Skin Disorder Pachyonychia Congenita. Hickerson, R.P., Smith, F.J., Irwin McLean, W.H., Landthaler, M., Leube, R.E., Kaspar, R.L. Ann. N. Y. Acad. Sci. (2006) [Pubmed]
 
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