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Gene Review

iroB  -  iron-related glycotransferase; similar to...

Escherichia coli

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Disease relevance of iroB


High impact information on iroB

  • Here, we report the purification of the IroB protein and its characterization as the Ent C-glucosyltransferase [2].
  • Five open reading frames were identified, three of which corresponded to genes encoding functions related to catechol-type siderophores: mchA and mchS1 are iroB and iroD homologues, respectively, and mchS4 was found to promote the production of the catecholate siderophore enterobactin [3].
  • An iroB-specific DNA probe detected homologous sequences in all strains of S. enterica, including serotypes of S. enterica subsp. enterica (I), salamae (II), diarizonae (IIIb), and houtenae (IV) [1].
  • The iroB gene of Salmonella enterica is absent from the chromosome of the related organism Escherichia coli [1].
  • A gene in this iro cluster, iroB, which encodes a putative glycosyltransferase, was also found in the microcin H47/M and microcin E492 gene clusters [4].

Biological context of iroB

  • The amino acid sequence of IroB, C, D, E and N was 95%, 86, 89, 96 and 96% identity to that of S. enterica serovar Typhi [5].

Associations of iroB with chemical compounds

  • A combination of preenrichment in buffered peptone water supplemented with ferrioxamine E and amplification of iroB by magnetic immuno-PCR allowed detection of S. enterica in albumen within 24 h [1].

Analytical, diagnostic and therapeutic context of iroB

  • Thus, PCR amplification of iroB can be used to distinguish between S. enterica and other bacterial species, including S. bongori [1].


  1. Rapid detection of Salmonella enterica with primers specific for iroB. Bäumler, A.J., Heffron, F., Reissbrodt, R. J. Clin. Microbiol. (1997) [Pubmed]
  2. In vitro characterization of IroB, a pathogen-associated C-glycosyltransferase. Fischbach, M.A., Lin, H., Liu, D.R., Walsh, C.T. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  3. Involvement of enterobactin synthesis pathway in production of microcin H47. Azpiroz, M.F., Laviña, M. Antimicrob. Agents Chemother. (2004) [Pubmed]
  4. The colicin G, H and X determinants encode microcins M and H47, which might utilize the catecholate siderophore receptors FepA, Cir, Fiu and IroN. Patzer, S.I., Baquero, M.R., Bravo, D., Moreno, F., Hantke, K. Microbiology (Reading, Engl.) (2003) [Pubmed]
  5. Cloning and characterization of an iron regulated locus, iroA, in Salmonella enterica serovar Choleraesuis. Wu, W.S., Hsieh, P.C., Huang, T.M., Chang, Y.F., Chang, C.F. DNA Seq. (2002) [Pubmed]
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