The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

Klp64D  -  Kinesin-like protein at 64D

Drosophila melanogaster

Synonyms: CG10642, DmKlp64D, Dmel\CG10642, KIF 3A, KIF3A, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on Klp64D

  • Immunostaining for KLP68D and ribonucleic acid in situ hybridization for KLP64D demonstrated their preferential expression in cholinergic neurons [1].
  • Soluble KIF2 exists without a light chain, and KIF2's associated-vesicles, immunoprecipitated by anti-KIF2 antibody, are different from those carried by existing motors such as kinesin and KIF3A [2].
  • All these defects are rescued by exclusive expression of DmKAP and KLP64D/KIF3A in the JO neurons of respective mutants [3].
  • Quantification analysis further showed that mutations in Klp64D could independently affect the anterograde transport of AChE even before that of ChAT [4].
  • Mutations in the kinesin-2 motor subunit Klp64D and separate siRNA-mediated knock-outs of all the three kinesin-2 subunits disrupt the ChAT and AChE transports, and these antigens accumulate in discrete nonoverlapping punctae in neuronal cell bodies and axons [4].
 

Anatomical context of Klp64D

 

Other interactions of Klp64D

  • Mutations in Klp64D, which codes for a Kinesin II motor subunit in Drosophila, show similar ciliary defects [3].

References

  1. Kinesin-II is required for axonal transport of choline acetyltransferase in Drosophila. Ray, K., Perez, S.E., Yang, Z., Xu, J., Ritchings, B.W., Steller, H., Goldstein, L.S. J. Cell Biol. (1999) [Pubmed]
  2. KIF2 is a new microtubule-based anterograde motor that transports membranous organelles distinct from those carried by kinesin heavy chain or KIF3A/B. Noda, Y., Sato-Yoshitake, R., Kondo, S., Nangaku, M., Hirokawa, N. J. Cell Biol. (1995) [Pubmed]
  3. Drosophila KAP interacts with the kinesin II motor subunit KLP64D to assemble chordotonal sensory cilia, but not sperm tails. Sarpal, R., Todi, S.V., Sivan-Loukianova, E., Shirolikar, S., Subramanian, N., Raff, E.C., Erickson, J.W., Ray, K., Eberl, D.F. Curr. Biol. (2003) [Pubmed]
  4. Kinesin-2 differentially regulates the anterograde axonal transports of acetylcholinesterase and choline acetyltransferase in Drosophila. Baqri, R., Charan, R., Schimmelpfeng, K., Chavan, S., Ray, K. J. Neurobiol. (2006) [Pubmed]
 
WikiGenes - Universities