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Gene Review

Klp64D  -  Kinesin-like protein at 64D

Drosophila melanogaster

Synonyms: CG10642, DmKlp64D, Dmel\CG10642, KIF 3A, KIF3A, ...
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High impact information on Klp64D

  • Immunostaining for KLP68D and ribonucleic acid in situ hybridization for KLP64D demonstrated their preferential expression in cholinergic neurons [1].
  • Soluble KIF2 exists without a light chain, and KIF2's associated-vesicles, immunoprecipitated by anti-KIF2 antibody, are different from those carried by existing motors such as kinesin and KIF3A [2].
  • All these defects are rescued by exclusive expression of DmKAP and KLP64D/KIF3A in the JO neurons of respective mutants [3].
  • Quantification analysis further showed that mutations in Klp64D could independently affect the anterograde transport of AChE even before that of ChAT [4].
  • Mutations in the kinesin-2 motor subunit Klp64D and separate siRNA-mediated knock-outs of all the three kinesin-2 subunits disrupt the ChAT and AChE transports, and these antigens accumulate in discrete nonoverlapping punctae in neuronal cell bodies and axons [4].

Anatomical context of Klp64D


Other interactions of Klp64D

  • Mutations in Klp64D, which codes for a Kinesin II motor subunit in Drosophila, show similar ciliary defects [3].


  1. Kinesin-II is required for axonal transport of choline acetyltransferase in Drosophila. Ray, K., Perez, S.E., Yang, Z., Xu, J., Ritchings, B.W., Steller, H., Goldstein, L.S. J. Cell Biol. (1999) [Pubmed]
  2. KIF2 is a new microtubule-based anterograde motor that transports membranous organelles distinct from those carried by kinesin heavy chain or KIF3A/B. Noda, Y., Sato-Yoshitake, R., Kondo, S., Nangaku, M., Hirokawa, N. J. Cell Biol. (1995) [Pubmed]
  3. Drosophila KAP interacts with the kinesin II motor subunit KLP64D to assemble chordotonal sensory cilia, but not sperm tails. Sarpal, R., Todi, S.V., Sivan-Loukianova, E., Shirolikar, S., Subramanian, N., Raff, E.C., Erickson, J.W., Ray, K., Eberl, D.F. Curr. Biol. (2003) [Pubmed]
  4. Kinesin-2 differentially regulates the anterograde axonal transports of acetylcholinesterase and choline acetyltransferase in Drosophila. Baqri, R., Charan, R., Schimmelpfeng, K., Chavan, S., Ray, K. J. Neurobiol. (2006) [Pubmed]
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