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Gene Review

Klp68D  -  Kinesin-like protein at 68D

Drosophila melanogaster

Synonyms: CG7293, DmKlp68D, Dmel\CG7293, KIF 3B, KIF3B, ...
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Disease relevance of Klp68D


High impact information on Klp68D


Biological context of Klp68D


Anatomical context of Klp68D

  • BACKGROUND: Kinesin II-mediated anterograde intraflagellar transport (IFT) is essential for the assembly and maintenance of flagella and cilia in various cell types [4].
  • However, the flagellar assembly in Drosophila spermatids does not require Kinesin II and is independent of IFT [4].
  • CONCLUSIONS: KAP plays an essential role in Kinesin II function, which is required for the axoneme growth and maintenance of the cilia in Drosophila type I sensory neurons [4].
  • Drosophila KAP interacts with the kinesin II motor subunit KLP64D to assemble chordotonal sensory cilia, but not sperm tails [4].

Physical interactions of Klp68D


Other interactions of Klp68D

  • The DmKAP expression pattern in the nervous system corresponds well with that of Klp64D and Klp68D as reported earlier [5].
  • Sequence analysis of a full-length cDNA encoding KLP68D demonstrates that this protein has a domain that shares significant sequence identity with the entire 340-amin acid kinesin heavy chain motor domain [1].


  1. Characterization of the KLP68D kinesin-like protein in Drosophila: possible roles in axonal transport. Pesavento, P.A., Stewart, R.J., Goldstein, L.S. J. Cell Biol. (1994) [Pubmed]
  2. Kinesin-II is required for axonal transport of choline acetyltransferase in Drosophila. Ray, K., Perez, S.E., Yang, Z., Xu, J., Ritchings, B.W., Steller, H., Goldstein, L.S. J. Cell Biol. (1999) [Pubmed]
  3. Follicle separation during Drosophila oogenesis requires the activity of the kinesin II-associated polypeptide Kap in germline cells. Pflanz, R., Peter, A., Schäfer, U., Jäckle, H. EMBO Rep. (2004) [Pubmed]
  4. Drosophila KAP interacts with the kinesin II motor subunit KLP64D to assemble chordotonal sensory cilia, but not sperm tails. Sarpal, R., Todi, S.V., Sivan-Loukianova, E., Shirolikar, S., Subramanian, N., Raff, E.C., Erickson, J.W., Ray, K., Eberl, D.F. Curr. Biol. (2003) [Pubmed]
  5. Dynamic expression pattern of kinesin accessory protein in Drosophila. Sarpal, R., Ray, K. J. Biosci. (2002) [Pubmed]
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