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Gene Review

Cha  -  Choline acetyltransferase

Drosophila melanogaster

Synonyms: CG12345, CHAT, CHOACTase, CLAT_DROME, CT23399, ...
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Disease relevance of Cha


High impact information on Cha


Chemical compound and disease context of Cha


Biological context of Cha


Anatomical context of Cha


Associations of Cha with chemical compounds


Physical interactions of Cha


Regulatory relationships of Cha

  • RNase protection analysis indicates that all Drosophila VAChT specific transcripts contain the shared first exon and suggests common transcriptional control for ChAT and VAChT [14].

Other interactions of Cha

  • The results obtained in these studies are discussed with respect to data presented on the adult distribution of the cholinergic markers' AChE activity and ChAT immunoreactivity [21].
  • Mutations in the kinesin-2 motor subunit Klp64D and separate siRNA-mediated knock-outs of all the three kinesin-2 subunits disrupt the ChAT and AChE transports, and these antigens accumulate in discrete nonoverlapping punctae in neuronal cell bodies and axons [9].
  • Choline acetyltransferase enzyme activity, protein levels, mRNA, and a fluorescent cholinergic reporter gene are all decreased in olfactory neurons of acj6 mutants [22].
  • A putative Drosophila melanogaster ortholog or paralog of peritrophin-55 (CG7714) was located within a 3458 bp intron of the Cha gene (choline-O-acetyltransferase), but on the opposite strand [23].
  • Transcriptional analysis of chromatin assembled with purified ACF and dNAP1 reveals that acetyl-CoA is required for preinitiation complex assembly [24].

Analytical, diagnostic and therapeutic context of Cha


  1. Altered electrical properties in Drosophila neurons developing without synaptic transmission. Baines, R.A., Uhler, J.P., Thompson, A., Sweeney, S.T., Bate, M. J. Neurosci. (2001) [Pubmed]
  2. Production of polyclonal antisera to choline acetyltransferase using a fusion protein produced by a cDNA clone. Muñoz-Maines, V.J., Slemmon, J.R., Panicker, M.M., Neighbor, N., Salvaterra, P.M. J. Neurochem. (1988) [Pubmed]
  3. Immunocytochemical study of a temperature-sensitive choline acetyltransferase mutant of Drosophila melanogaster. Ikeda, K., Salvaterra, P.M. J. Comp. Neurol. (1989) [Pubmed]
  4. In vitro transcription system delineates the distinct roles of the coactivators pCAF and p300 during MyoD/E47-dependent transactivation. Dilworth, F.J., Seaver, K.J., Fishburn, A.L., Htet, S.L., Tapscott, S.J. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  5. Adaptation to alcoholic fermentation in Drosophila: a parallel selection imposed by environmental ethanol and acetic acid. Chakir, M., Peridy, O., Capy, P., Pla, E., David, J.R. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  6. Evolutionary origin of cholinergic macromolecules and thyroglobulin. Mori, N., Itoh, N., Salvaterra, P.M. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  7. A POU homeo domain protein related to dPOU-19/pdm-1 binds to the regulatory DNA necessary for vital expression of the Drosophila choline acetyltransferase gene. Kitamoto, T., Salvaterra, P.M. J. Neurosci. (1995) [Pubmed]
  8. Expression, purification, and characterization of recombinant Drosophila choline acetyltransferase. Wu, D., Schormann, N., Lian, W., Deisenhofer, J., Hersh, L.B. J. Neurochem. (1993) [Pubmed]
  9. Kinesin-2 differentially regulates the anterograde axonal transports of acetylcholinesterase and choline acetyltransferase in Drosophila. Baqri, R., Charan, R., Schimmelpfeng, K., Chavan, S., Ray, K. J. Neurobiol. (2006) [Pubmed]
  10. In vitro neuronal differentiation of Drosophila embryo cells. Salvaterra, P.M., Bournias-Vardiabasis, N., Nair, T., Hou, G., Lieu, C. J. Neurosci. (1987) [Pubmed]
  11. Genomic organization of Drosophila choline acetyltransferase. Sugihara, H., Andrisani, V., Salvaterra, P.M. J. Neurochem. (1991) [Pubmed]
  12. Functional analysis of conserved histidines in choline acetyltransferase by site-directed mutagenesis. Carbini, L.A., Hersh, L.B. J. Neurochem. (1993) [Pubmed]
  13. Synaptic organization of the mushroom body calyx in Drosophila melanogaster. Yasuyama, K., Meinertzhagen, I.A., Schürmann, F.W. J. Comp. Neurol. (2002) [Pubmed]
  14. Structure and organization of the Drosophila cholinergic locus. Kitamoto, T., Wang, W., Salvaterra, P.M. J. Biol. Chem. (1998) [Pubmed]
  15. Localization of Drosophila neurons that contain choline acetyltransferase messenger RNA: an in situ hybridization study. Barber, R.P., Sugihara, H., Lee, M., Vaughn, J.E., Salvaterra, P.M. J. Comp. Neurol. (1989) [Pubmed]
  16. Immunoreactivity against choline acetyltransferase, gamma-aminobutyric acid, histamine, octopamine, and serotonin in the larval chemosensory system of Dosophila melanogaster. Python, F., Stocker, R.F. J. Comp. Neurol. (2002) [Pubmed]
  17. Extraretinal photoreceptors at the compound eye's posterior margin in Drosophila melanogaster. Yasuyama, K., Meinertzhagen, I.A. J. Comp. Neurol. (1999) [Pubmed]
  18. Choline acetyltransferase and acetylcholine levels in Drosophila melanogaster: a study using two temperature-sensitive mutants. Salvaterra, P.M., McCaman, R.E. J. Neurosci. (1985) [Pubmed]
  19. Sequence analysis of a proteolyzed site in Drosophila choline acetyltransferase. Slemmon, J.R. J. Neurochem. (1989) [Pubmed]
  20. Follicle separation during Drosophila oogenesis requires the activity of the kinesin II-associated polypeptide Kap in germline cells. Pflanz, R., Peter, A., Schäfer, U., Jäckle, H. EMBO Rep. (2004) [Pubmed]
  21. On the role of normal acetylcholine metabolism in the formation and maintenance of the Drosophila nervous system. Chase, B.A., Kankel, D.R. Dev. Biol. (1988) [Pubmed]
  22. Abnormal chemosensory jump 6 is a positive transcriptional regulator of the cholinergic gene locus in Drosophila olfactory neurons. Lee, M.H., Salvaterra, P.M. J. Neurosci. (2002) [Pubmed]
  23. Identification of an immuno-protective mucin-like protein, peritrophin-55, from the peritrophic matrix of Lucilia cuprina larvae. Tellam, R.L., Vuocolo, T., Eisemann, C., Briscoe, S., Riding, G., Elvin, C., Pearson, R. Insect Biochem. Mol. Biol. (2003) [Pubmed]
  24. Transcriptional analysis of chromatin assembled with purified ACF and dNAP1 reveals that acetyl-CoA is required for preinitiation complex assembly. Jiang, W., Nordeen, S.K., Kadonaga, J.T. J. Biol. Chem. (2000) [Pubmed]
  25. Isolation and characterization of mutants for the vesicular acetylcholine transporter gene in Drosophila melanogaster. Kitamoto, T., Xie, X., Wu, C.F., Salvaterra, P.M. J. Neurobiol. (2000) [Pubmed]
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