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Gene Review

Kif3a  -  kinesin family member 3A

Mus musculus

Synonyms: AW124694, Kif3, Kifl, Kinesin-like protein KIF3A, Kns3, ...
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Disease relevance of Kif3a

  • Cyst formation, aberrant ductal morphology, and extensive fibrosis associated with severe adhesion to adjacent organs were commonly observed in aged Kif3a mutant mice [1].
  • Results: Tissue-specific loss of Kif3a in pancreatic cells resulted in severe pancreatic abnormalities including acinar-to-ductal metaplasia, fibrosis, and lipomatosis [1].
  • Using neuroblastoma cells as an in vitro model for neuronal differentiation, we found that retinoic acid stimulated the expression of the three Kif3 and the kinesin-associated protein genes, although with different time courses [2].

High impact information on Kif3a

  • Deletion of Kif3a using different pancreas-specific Cre strains suggests that these pancreatic phenotypes might be caused by the absence of cilia in ductal cells [1].
  • We have previously shown that mouse mutants for two IFT proteins, IFT88 and IFT172, as well as Kif3a, a subunit of mouse kinesin 2, exhibit ventral spinal cord patterning defects that appear to result from reduced hedgehog (Hh) signaling [3].
  • Analysis of Kinesin-2 Function in Photoreceptor Cells Using Synchronous Cre-loxP Knockout of Kif3a with RHO-Cre [4].
  • Cluster analysis revealed BDNF signalling-mediated regulation of functional gene classes involved in cellular transport, DNA repair and cell death, including kinesin motor kinesin family member 3A involved in cellular transport [5].
  • Genetic analysis shows that Wim, Polaris and the IFT motor protein Kif3a are required for Hedgehog signalling at a step downstream of Patched1 (the Hedgehog receptor) and upstream of direct targets of Hedgehog signalling [6].


  1. Primary cilia deletion in pancreatic epithelial cells results in cyst formation and pancreatitis. Cano, D.A., Sekine, S., Hebrok, M. Gastroenterology (2006) [Pubmed]
  2. Expression of KIF3C kinesin during neural development and in vitro neuronal differentiation. Navone, F., Consalez, G.G., Sardella, M., Caspani, E., Pozzoli, O., Frassoni, C., Morlacchi, E., Sitia, R., Sprocati, T., Cabibbo, A. J. Neurochem. (2001) [Pubmed]
  3. Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors. Liu, A., Wang, B., Niswander, L.A. Development (2005) [Pubmed]
  4. Analysis of Kinesin-2 Function in Photoreceptor Cells Using Synchronous Cre-loxP Knockout of Kif3a with RHO-Cre. Jimeno, D., Feiner, L., Lillo, C., Teofilo, K., Goldstein, L.S., Pierce, E.A., Williams, D.S. Invest. Ophthalmol. Vis. Sci. (2006) [Pubmed]
  5. Brain-derived neurotrophic factor signaling modifies hippocampal gene expression during epileptogenesis in transgenic mice. Lähteinen, S., Pitkänen, A., Knuuttila, J., Törönen, P., Castrén, E. Eur. J. Neurosci. (2004) [Pubmed]
  6. Hedgehog signalling in the mouse requires intraflagellar transport proteins. Huangfu, D., Liu, A., Rakeman, A.S., Murcia, N.S., Niswander, L., Anderson, K.V. Nature (2003) [Pubmed]
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