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Gene Review

KIF3A  -  kinesin family member 3A

Homo sapiens

Synonyms: FLA10, KIF3, KLP-20, Kinesin-like protein KIF3A, Microtubule plus end-directed kinesin motor 3A
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Disease relevance of KIF3A


High impact information on KIF3A


Biological context of KIF3A


Anatomical context of KIF3A

  • Inhibition of KIF3A expression caused neurite retraction and inhibited tau mRNA axonal targeting [9].
  • Instead, the data are consistent with a coordinated head model in which detachment of the slow KIF3A head from the microtubule is accelerated roughly threefold by the KIF3B head [10].
  • Recently, we showed that the KIF3A subunit of kinesin II is concentrated in the inner segment and connecting cilium of fish photoreceptors [11].
  • KIF3A/B: a heterodimeric kinesin superfamily protein that works as a microtubule plus end-directed motor for membrane organelle transport [1].
  • In contrast to KIF3A and KIF3B, Northern and Western analysis indicated that KIF3C expression is highly enriched in neural tissues such as brain, spinal cord, and retina [8].

Associations of KIF3A with chemical compounds


Other interactions of KIF3A

  • Third, the KIF3A/A homodimer moves fivefold slower than wild-type, demonstrating distinct functional differences between the two heads [10].
  • These data, combined with previous data from other labs, indicate that KIF3C and KIF3B are "variable" subunits that associate with a common KIF3A subunit, but not with each other [8].
  • Additional immunoprecipitation studies revealed the association of RPGR-ORF15 isoform(s) with the intraflagellar transport polypeptide IFT88 as well as microtubule motor proteins, including KIF3A, p150Glued, and p50-dynamitin [15].
  • Immunofluorescent staining also showed substantial PC2 and KIF3A co-localization in primary cilia of renal epithelial cells [16].
  • Using the yeast two-hybrid assay, we found that PC2 interacts with the microtubule-dependent motor kinesin-2 subunit KIF3A, a protein involved in polycystic kidney disease [16].

Analytical, diagnostic and therapeutic context of KIF3A


  1. KIF3A/B: a heterodimeric kinesin superfamily protein that works as a microtubule plus end-directed motor for membrane organelle transport. Yamazaki, H., Nakata, T., Okada, Y., Hirokawa, N. J. Cell Biol. (1995) [Pubmed]
  2. Kidney-specific inactivation of the KIF3A subunit of kinesin-II inhibits renal ciliogenesis and produces polycystic kidney disease. Lin, F., Hiesberger, T., Cordes, K., Sinclair, A.M., Goldstein, L.S., Somlo, S., Igarashi, P. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  3. Genetic evidence for selective transport of opsin and arrestin by kinesin-II in mammalian photoreceptors. Marszalek, J.R., Liu, X., Roberts, E.A., Chui, D., Marth, J.D., Williams, D.S., Goldstein, L.S. Cell (2000) [Pubmed]
  4. Dual use of the transcriptional repressor (CtBP2)/ribbon synapse (RIBEYE) gene: how prevalent are multifunctional genes? Piatigorsky, J. Trends Neurosci. (2001) [Pubmed]
  5. The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3. Nagata, K., Puls, A., Futter, C., Aspenstrom, P., Schaefer, E., Nakata, T., Hirokawa, N., Hall, A. EMBO J. (1998) [Pubmed]
  6. Role of the kinesin-2 family protein, KIF3, during mitosis. Haraguchi, K., Hayashi, T., Jimbo, T., Yamamoto, T., Akiyama, T. J. Biol. Chem. (2006) [Pubmed]
  7. VISTA: computational tools for comparative genomics. Frazer, K.A., Pachter, L., Poliakov, A., Rubin, E.M., Dubchak, I. Nucleic Acids Res. (2004) [Pubmed]
  8. Characterization of the KIF3C neural kinesin-like motor from mouse. Yang, Z., Goldstein, L.S. Mol. Biol. Cell (1998) [Pubmed]
  9. Visualization of translated tau protein in the axons of neuronal P19 cells and characterization of tau RNP granules. Aronov, S., Aranda, G., Behar, L., Ginzburg, I. J. Cell. Sci. (2002) [Pubmed]
  10. The two motor domains of KIF3A/B coordinate for processive motility and move at different speeds. Zhang, Y., Hancock, W.O. Biophys. J. (2004) [Pubmed]
  11. Photoreceptor localization of the KIF3A and KIF3B subunits of the heterotrimeric microtubule motor kinesin II in vertebrate retina. Whitehead, J.L., Wang, S.Y., Bost-Usinger, L., Hoang, E., Frazer, K.A., Burnside, B. Exp. Eye Res. (1999) [Pubmed]
  12. Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1. Surpili, M.J., Delben, T.M., Kobarg, J. Biochemistry (2003) [Pubmed]
  13. Interaction between GADD34 and kinesin superfamily, KIF3A. Hasegawa, T., Yagi, A., Isobe, K. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  14. Kinesin family in murine central nervous system. Aizawa, H., Sekine, Y., Takemura, R., Zhang, Z., Nangaku, M., Hirokawa, N. J. Cell Biol. (1992) [Pubmed]
  15. RPGR-ORF15, which is mutated in retinitis pigmentosa, associates with SMC1, SMC3, and microtubule transport proteins. Khanna, H., Hurd, T.W., Lillo, C., Shu, X., Parapuram, S.K., He, S., Akimoto, M., Wright, A.F., Margolis, B., Williams, D.S., Swaroop, A. J. Biol. Chem. (2005) [Pubmed]
  16. Polycystin-2 Cation Channel Function Is under the Control of Microtubular Structures in Primary Cilia of Renal Epithelial Cells. Li, Q., Montalbetti, N., Wu, Y., Ramos, A., Raychowdhury, M.K., Chen, X.Z., Cantiello, H.F. J. Biol. Chem. (2006) [Pubmed]
  17. Localization of kinesin superfamily proteins to the connecting cilium of fish photoreceptors. Beech, P.L., Pagh-Roehl, K., Noda, Y., Hirokawa, N., Burnside, B., Rosenbaum, J.L. J. Cell. Sci. (1996) [Pubmed]
  18. Analysis of Kinesin-2 Function in Photoreceptor Cells Using Synchronous Cre-loxP Knockout of Kif3a with RHO-Cre. Jimeno, D., Feiner, L., Lillo, C., Teofilo, K., Goldstein, L.S., Pierce, E.A., Williams, D.S. Invest. Ophthalmol. Vis. Sci. (2006) [Pubmed]
  19. Molecular cloning and expression of the KIF3A gene in the frog brain and testis. Nakajima, T., Miura, I., Kashiwagi, A., Nakamura, M. Zool. Sci. (1997) [Pubmed]
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