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Gene Review

SETD8  -  SET domain containing (lysine...

Homo sapiens

Synonyms: H4-K20-HMTase SETD8, Histone-lysine N-methyltransferase SETD8, KMT5A, Lysine N-methyltransferase 5A, N-lysine methyltransferase SETD8, ...
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Disease relevance of SETD8


High impact information on SETD8


Biological context of SETD8


Associations of SETD8 with chemical compounds

  • We have purified a human histone H4 lysine 20 methyltransferase and cloned the encoding gene, PR/SET07 [6].


  1. An miR-502-binding site single-nucleotide polymorphism in the 3'-untranslated region of the SET8 gene is associated with early age of breast cancer onset. Song, F., Zheng, H., Liu, B., Wei, S., Dai, H., Zhang, L., Calin, G.A., Hao, X., Wei, Q., Zhang, W., Chen, K. Clin. Cancer Res. (2009) [Pubmed]
  2. Structural and functional analysis of SET8, a histone H4 Lys-20 methyltransferase. Couture, J.F., Collazo, E., Brunzelle, J.S., Trievel, R.C. Genes Dev. (2005) [Pubmed]
  3. Mitotic-specific methylation of histone H4 Lys 20 follows increased PR-Set7 expression and its localization to mitotic chromosomes. Rice, J.C., Nishioka, K., Sarma, K., Steward, R., Reinberg, D., Allis, C.D. Genes Dev. (2002) [Pubmed]
  4. Purification and functional characterization of SET8, a nucleosomal histone H4-lysine 20-specific methyltransferase. Fang, J., Feng, Q., Ketel, C.S., Wang, H., Cao, R., Xia, L., Erdjument-Bromage, H., Tempst, P., Simon, J.A., Zhang, Y. Curr. Biol. (2002) [Pubmed]
  5. A switch in mitotic histone H4 lysine 20 methylation status is linked to M phase defects upon loss of HCF-1. Julien, E., Herr, W. Mol. Cell (2004) [Pubmed]
  6. PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin. Nishioka, K., Rice, J.C., Sarma, K., Erdjument-Bromage, H., Werner, J., Wang, Y., Chuikov, S., Valenzuela, P., Tempst, P., Steward, R., Lis, J.T., Allis, C.D., Reinberg, D. Mol. Cell (2002) [Pubmed]
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