Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

cer1 - cerberus 1, DAN family BMP antagonist

Xenopus (Silurana) tropicalis

Synonyms: cer, cer-1, dand4, tCerberus, xcer, ...

Stanley, E. et al., Zamparini, A.L. et al., Shawlot, W. et al., Shawlot, W. et al., Simpson, E.H. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on cer1

The Xenopus cerberus gene encodes a secreted factor that is expressed in the anterior endomesoderm of gastrula stage embryos and can induce the formation of ectopic heads when its mRNA is injected into Xenopus embryos [Bouwmeester, T., Kim, S., Lu, B. & De Robertis, E. M. (1996) Nature (London) 382, 595-601] [1].
This Hex-mediated enhancement of Wnt signalling results in the upregulation of the Nieuwkoop centre genes Siamois and Xnr3, and the subsequent increased expression of the anterior endodermal marker Cerberus and other mesendodermal genes downstream of Wnt signalling [2].
Cer1 is the mouse homologue of the Xenopus Cerberus gene whose product is able to induce development of head structures during embryonic development [3].
The Xenopus cerberus gene encodes a secreted factor expressed in the Spemann organizer that can cause ectopic head formation when its mRNA is injected into Xenopus embryos [4].
DAN is a secreted glycoprotein related to Xenopus cerberus [5].

Biological context of cer1

We report that DAN, a potential cell cycle regulator and tumour suppressor, is a secreted glycoprotein related to Xenopus cerberus [5].

References

Expression of the mouse cerberus-related gene, Cerr1, suggests a role in anterior neural induction and somitogenesis. Shawlot, W., Deng, J.M., Behringer, R.R. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
Hex acts with {beta}-catenin to regulate anteroposterior patterning via a Groucho-related co-repressor and Nodal. Zamparini, A.L., Watts, T., Gardner, C.E., Tomlinson, S.R., Johnston, G.I., Brickman, J.M. Development (2006) [Pubmed]
The mouse Cer1 (Cerberus related or homologue) gene is not required for anterior pattern formation. Simpson, E.H., Johnson, D.K., Hunsicker, P., Suffolk, R., Jordan, S.A., Jackson, I.J. Dev. Biol. (1999) [Pubmed]
The cerberus-related gene, Cerr1, is not essential for mouse head formation. Shawlot, W., Min Deng, J., Wakamiya, M., Behringer, R.R. Genesis (2000) [Pubmed]
DAN is a secreted glycoprotein related to Xenopus cerberus. Stanley, E., Biben, C., Kotecha, S., Fabri, L., Tajbakhsh, S., Wang, C.C., Hatzistavrou, T., Roberts, B., Drinkwater, C., Lah, M., Buckingham, M., Hilton, D., Nash, A., Mohun, T., Harvey, R.P. Mech. Dev. (1998) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.