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Gene Review

cer1  -  cerberus 1, DAN family BMP antagonist

Xenopus (Silurana) tropicalis

Synonyms: cer, cer-1, dand4, tCerberus, xcer, ...
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High impact information on cer1

  • The Xenopus cerberus gene encodes a secreted factor that is expressed in the anterior endomesoderm of gastrula stage embryos and can induce the formation of ectopic heads when its mRNA is injected into Xenopus embryos [Bouwmeester, T., Kim, S., Lu, B. & De Robertis, E. M. (1996) Nature (London) 382, 595-601] [1].
  • This Hex-mediated enhancement of Wnt signalling results in the upregulation of the Nieuwkoop centre genes Siamois and Xnr3, and the subsequent increased expression of the anterior endodermal marker Cerberus and other mesendodermal genes downstream of Wnt signalling [2].
  • Cer1 is the mouse homologue of the Xenopus Cerberus gene whose product is able to induce development of head structures during embryonic development [3].
  • The Xenopus cerberus gene encodes a secreted factor expressed in the Spemann organizer that can cause ectopic head formation when its mRNA is injected into Xenopus embryos [4].
  • DAN is a secreted glycoprotein related to Xenopus cerberus [5].

Biological context of cer1


  1. Expression of the mouse cerberus-related gene, Cerr1, suggests a role in anterior neural induction and somitogenesis. Shawlot, W., Deng, J.M., Behringer, R.R. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  2. Hex acts with {beta}-catenin to regulate anteroposterior patterning via a Groucho-related co-repressor and Nodal. Zamparini, A.L., Watts, T., Gardner, C.E., Tomlinson, S.R., Johnston, G.I., Brickman, J.M. Development (2006) [Pubmed]
  3. The mouse Cer1 (Cerberus related or homologue) gene is not required for anterior pattern formation. Simpson, E.H., Johnson, D.K., Hunsicker, P., Suffolk, R., Jordan, S.A., Jackson, I.J. Dev. Biol. (1999) [Pubmed]
  4. The cerberus-related gene, Cerr1, is not essential for mouse head formation. Shawlot, W., Min Deng, J., Wakamiya, M., Behringer, R.R. Genesis (2000) [Pubmed]
  5. DAN is a secreted glycoprotein related to Xenopus cerberus. Stanley, E., Biben, C., Kotecha, S., Fabri, L., Tajbakhsh, S., Wang, C.C., Hatzistavrou, T., Roberts, B., Drinkwater, C., Lah, M., Buckingham, M., Hilton, D., Nash, A., Mohun, T., Harvey, R.P. Mech. Dev. (1998) [Pubmed]
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