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Gene Review

Cer1  -  cerberus 1 homolog (Xenopus laevis)

Mus musculus

Synonyms: Cer-l, Cerberus, Cerberus-like, Cerberus-like protein, Cerberus-related protein, ...
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High impact information on Cer1

  • Antagonistic signaling by Caronte, a novel Cerberus-related gene, establishes left-right asymmetric gene expression [1].
  • Germ layer explant recombination assays demonstrated that Cerr1-expressing somitic-presomitic mesoderm, but not older Cerr1-nonexpressing somitic mesoderm, was able to mimic the anterior neuralizing ability of anterior mesendoderm and maintain Otx2 expression in competent ectoderm [2].
  • In most Lim1-/- headless embryos, Cerr1 expression in the anterior endoderm was weak or absent [2].
  • In somite stage embryos, Cerr1 expression is restricted to the most recently formed somites and in the anterior presomitic mesoderm [2].
  • Analysis of a mouse interspecific backcross panel demonstrated that Cerr1 mapped to the central portion of mouse chromosome 4 [2].

Biological context of Cer1


Anatomical context of Cer1


Associations of Cer1 with chemical compounds

  • Epitope-tagged versions of Cer1 show that, unlike in TGFbeta superfamily members, the cysteine knot motif is not processed away from a proprotein [7].

Physical interactions of Cer1

  • Here we show that the neural-inducing and mesoderm-inhibiting activities of Cer-l result from specific binding to BMP and Nodal molecules, respectively [9].

Other interactions of Cer1

  • In mouse, the cerberus-related gene, Cerr1, is expressed in the anterior mesendoderm that underlies the presumptive anterior neural plate and its expression is downregulated in Lim1 headless embryos [8].
  • This defect is not rescued in chimeras containing wild-type embryonic, and Cerberus-like(-/-);Lefty1(-/-) extraembryonic, cells but is rescued in Cerberus-like(-/-); Lefty1(-/-) embryos after removal of one copy of the Nodal gene [10].
  • The BMP antagonists cerberus-like and noggin do not interact during mouse forebrain development [11].


  1. Antagonistic signaling by Caronte, a novel Cerberus-related gene, establishes left-right asymmetric gene expression. Yokouchi, Y., Vogan, K.J., Pearse, R.V., Tabin, C.J. Cell (1999) [Pubmed]
  2. Expression of the mouse cerberus-related gene, Cerr1, suggests a role in anterior neural induction and somitogenesis. Shawlot, W., Deng, J.M., Behringer, R.R. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  3. The mouse Cer1 (Cerberus related or homologue) gene is not required for anterior pattern formation. Simpson, E.H., Johnson, D.K., Hunsicker, P., Suffolk, R., Jordan, S.A., Jackson, I.J. Dev. Biol. (1999) [Pubmed]
  4. Goosecoid and cerberus-like do not interact during mouse embryogenesis. Borges, A.C., Marques, S., Belo, J.A. Int. J. Dev. Biol. (2002) [Pubmed]
  5. Targeted insertion of a lacZ reporter gene into the mouse Cer1 locus reveals complex and dynamic expression during embryogenesis. Stanley, E.G., Biben, C., Allison, J., Hartley, L., Wicks, I.P., Campbell, I.K., McKinley, M., Barnett, L., Koentgen, F., Robb, L., Harvey, R.P. Genesis (2000) [Pubmed]
  6. Murine cerberus homologue Cer1 maps to chromosome 4. Stanley, E., Gilbert, D.G., Jenkins, N.A., Copeland, N.G., Harvey, R.P. Genomics (1998) [Pubmed]
  7. A mouse cerberus/Dan-related gene family. Pearce, J.J., Penny, G., Rossant, J. Dev. Biol. (1999) [Pubmed]
  8. The cerberus-related gene, Cerr1, is not essential for mouse head formation. Shawlot, W., Min Deng, J., Wakamiya, M., Behringer, R.R. Genesis (2000) [Pubmed]
  9. Cerberus-like is a secreted BMP and nodal antagonist not essential for mouse development. Belo, J.A., Bachiller, D., Agius, E., Kemp, C., Borges, A.C., Marques, S., Piccolo, S., De Robertis, E.M. Genesis (2000) [Pubmed]
  10. Nodal antagonists in the anterior visceral endoderm prevent the formation of multiple primitive streaks. Perea-Gomez, A., Vella, F.D., Shawlot, W., Oulad-Abdelghani, M., Chazaud, C., Meno, C., Pfister, V., Chen, L., Robertson, E., Hamada, H., Behringer, R.R., Ang, S.L. Dev. Cell (2002) [Pubmed]
  11. The BMP antagonists cerberus-like and noggin do not interact during mouse forebrain development. Borges, A.C., Marques, S., Belo, J.A. Int. J. Dev. Biol. (2001) [Pubmed]
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