Gene Review:
Hhex - hematopoietically expressed homeobox
Mus musculus
Synonyms:
Hematopoietically-expressed homeobox protein Hhex, Hex, Hex1, Hhex-rs2, Homeobox protein HEX, ...
- The homeobox gene Hex induces T-cell-derived lymphomas when overexpressed in hematopoietic precursor cells. George, A., Morse, H.C., Justice, M.J. Oncogene (2003)
- Immunocytochemical characterization of murine Hex, a homeobox-containing protein. Ghosh, B., Ganea, G.R., Denson, L.A., Iannucci, R., Jacobs, H.C., Bogue, C.W. Pediatr. Res. (2000)
- Apoptotic cell death in mouse models of GM2 gangliosidosis and observations on human Tay-Sachs and Sandhoff diseases. Huang, J.Q., Trasler, J.M., Igdoura, S., Michaud, J., Hanal, N., Gravel, R.A. Hum. Mol. Genet. (1997)
- A direct gene transfer strategy via brain internal capsule reverses the biochemical defect in Tay-Sachs disease. Martino, S., Marconi, P., Tancini, B., Dolcetta, D., De Angelis, M.G., Montanucci, P., Bregola, G., Sandhoff, K., Bordignon, C., Emiliani, C., Manservigi, R., Orlacchio, A. Hum. Mol. Genet. (2005)
- The organizer factors Chordin and Noggin are required for mouse forebrain development. Bachiller, D., Klingensmith, J., Kemp, C., Belo, J.A., Anderson, R.M., May, S.R., McMahon, J.A., McMahon, A.P., Harland, R.M., Rossant, J., De Robertis, E.M. Nature (2000)
- Heart induction by Wnt antagonists depends on the homeodomain transcription factor Hex. Foley, A.C., Mercola, M. Genes Dev. (2005)
- Impaired B cell development and function in mice with a targeted disruption of the homeobox gene Hex. Bogue, C.W., Zhang, P.X., McGrath, J., Jacobs, H.C., Fuleihan, R.L. Proc. Natl. Acad. Sci. U.S.A. (2003)
- A null mutation of Hhex results in abnormal cardiac development, defective vasculogenesis and elevated Vegfa levels. Hallaq, H., Pinter, E., Enciso, J., McGrath, J., Zeiss, C., Brueckner, M., Madri, J., Jacobs, H.C., Wilson, C.M., Vasavada, H., Jiang, X., Bogue, C.W. Development (2004)
- The homeobox gene HEX regulates proliferation and differentiation of hemangioblasts and endothelial cells during ES cell differentiation. Kubo, A., Chen, V., Kennedy, M., Zahradka, E., Daley, G.Q., Keller, G. Blood (2005)
- Regulation of Hex gene expression by a Smads-dependent signaling pathway. Zhang, W., Yatskievych, T.A., Cao, X., Antin, P.B. J. Biol. Chem. (2002)
- HNF3beta and GATA-4 transactivate the liver-enriched homeobox gene, Hex. Denson, L.A., McClure, M.H., Bogue, C.W., Karpen, S.J., Jacobs, H.C. Gene (2000)
- Photoaffinity labeling of human lysosomal beta-hexosaminidase B. Identification of Glu-355 at the substrate binding site. Liessem, B., Glombitza, G.J., Knoll, F., Lehmann, J., Kellermann, J., Lottspeich, F., Sandhoff, K. J. Biol. Chem. (1995)
- Pharmacological and kinetic properties of alpha 4 beta 2 neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes. Charnet, P., Labarca, C., Cohen, B.N., Davidson, N., Lester, H.A., Pilar, G. J. Physiol. (Lond.) (1992)
- Characterization of the testis and epididymis in mouse models of human Tay Sachs and Sandhoff diseases and partial determination of accumulated gangliosides. Trasler, J., Saberi, F., Somani, I.H., Adamali, H.I., Huang, J.Q., Fortunato, S.R., Ritter, G., Gu, M., Aebersold, R., Gravel, R.A., Hermo, L. Endocrinology (1998)
- Thyroid-specific transcription factors control Hex promoter activity. Puppin, C., D'Elia, A.V., Pellizzari, L., Russo, D., Arturi, F., Presta, I., Filetti, S., Bogue, C.W., Denson, L.A., Damante, G. Nucleic Acids Res. (2003)
- Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas. Bort, R., Martinez-Barbera, J.P., Beddington, R.S., Zaret, K.S. Development (2004)
- Hex: a homeobox gene revealing peri-implantation asymmetry in the mouse embryo and an early transient marker of endothelial cell precursors. Thomas, P.Q., Brown, A., Beddington, R.S. Development (1998)
- Homeobox protein Hex induces SMemb/nonmuscle myosin heavy chain-B gene expression through the cAMP-responsive element. Sekiguchi, K., Kurabayashi, M., Oyama, Y., Aihara, Y., Tanaka, T., Sakamoto, H., Hoshino, Y., Kanda, T., Yokoyama, T., Shimomura, Y., Iijima, H., Ohyama, Y., Nagai, R. Circ. Res. (2001)
- Retinoic acid generated by Raldh2 in mesoderm is required for mouse dorsal endodermal pancreas development. Molotkov, A., Molotkova, N., Duester, G. Dev. Dyn. (2005)
- Postgastrulation Smad2-deficient embryos show defects in embryo turning and anterior morphogenesis. Heyer, J., Escalante-Alcalde, D., Lia, M., Boettinger, E., Edelmann, W., Stewart, C.L., Kucherlapati, R. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Hex acts with {beta}-catenin to regulate anteroposterior patterning via a Groucho-related co-repressor and Nodal. Zamparini, A.L., Watts, T., Gardner, C.E., Tomlinson, S.R., Johnston, G.I., Brickman, J.M. Development (2006)
- Hhex is a direct repressor of endothelial cell-specific molecule 1 (ESM-1). Cong, R., Jiang, X., Wilson, C.M., Hunter, M.P., Vasavada, H., Bogue, C.W. Biochem. Biophys. Res. Commun. (2006)
- Expression of Hex mRNA in early murine postimplantation embryo development. Keng, V.W., Fujimori, K.E., Myint, Z., Tamamaki, N., Nojyo, Y., Noguchi, T. FEBS Lett. (1998)