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Gene Review:

Sfrp1 - secreted frizzled-related protein 1

Rattus norvegicus

Synonyms: Secreted frizzled-related protein 1, sFRP-1

Yoshino, K. et al., Bergwitz, C. et al., Katoh, Y. et al., Drake, J.M. et al.

Yoshino, Rubin, Higinbotham, Uren, Anest, Plisov, Perantoni, Bergwitz, Wendlandt, Kispert, Brabant,

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High impact information on Sfrp1

These observations suggest that sFRP-1 and sFRP-2 compete locally to regulate Wnt signaling during renal organogenesis [1].
In cultures of isolated, induced rat metanephric mesenchymes, sFRP-1 blocked events associated with epithelial conversion (tubulogenesis and expression of lim-1, sfrp-2 and E-cadherin); however, it had no demonstrable effect on early events (compaction of mesenchyme and expression of wt1) [1].
Rat Sfrp1 gene, consisting of three exons, was located within AC112899.4 genome sequence [2].
Here, we identified and characterized the rat Sfrp1 gene by using bioinformatics [2].
The role of sFRP4, a secreted frizzled-related protein, in ovulation [3].

Anatomical context of Sfrp1

To investigate their function during chondrocyte differentiation, we used NIH3T3 cells producing seven members of the Wnt family and secreted frizzled-related protein (sFRP-2) for co-culture experiments with the rat chondrogenic cell line pColl(II)-EGFP-5 [4].

References

Secreted Frizzled-related proteins can regulate metanephric development. Yoshino, K., Rubin, J.S., Higinbotham, K.G., Uren, A., Anest, V., Plisov, S.Y., Perantoni, A.O. Mech. Dev. (2001) [Pubmed]
Comparative genomics on SFRP1 orthologs. Katoh, Y., Katoh, M. Int. J. Oncol. (2005) [Pubmed]
The role of sFRP4, a secreted frizzled-related protein, in ovulation. Drake, J.M., Friis, R.R., Dharmarajan, A.M. Apoptosis (2003) [Pubmed]
Wnts differentially regulate colony growth and differentiation of chondrogenic rat calvaria cells. Bergwitz, C., Wendlandt, T., Kispert, A., Brabant, G. Biochim. Biophys. Acta (2001) [Pubmed]

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SFRP1	Bos taurus
SFRP1	Canis lupus familiaris
sfrp1b	Danio rerio
sfrp1a	Danio rerio
SFRP1	Gallus gallus
SFRP1	Homo sapiens
SFRP1	Macaca mulatta
Sfrp1	Mus musculus
SFRP1	Pan troglodytes
sfrp1	Xenopus (Silurana) tropicalis

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