Disease relevance of SFRP1

• SFRP1 tumor suppressor gene at human chromosome 8p11.21 is inactivated in colorectal cancer and other tumors by deletion and by epigenetic CpG hypermethylation [1].

High impact information on SFRP1

• Transient transfection assays and an assay using addition of purified protein indicate that FrzA reduces the proliferation of endothelial cells [2].
• Analysis of its expression in endothelium revealed that FrzA mRNA levels were high in endothelial cells scraped from freshly obtained bovine aortas, decreased when cells were placed in culture and began to proliferate, but increased at confluence [2].
• One of these proteins, FrzA, the bovine counterpart of the murine sFRP-1 (93% identity) is involved in vascular cell growth control, binds Wg in vitro and antagonizes Xwnt-8 and hWnt-2 signaling in Xenopus embryos (Xu et al. , 1998; Duplàa et al., 1999) [3].
• Comparative genomics on SFRP1 orthologs [1].

Analytical, diagnostic and therapeutic context of SFRP1

• Immunoprecipitation experiments demonstrates that FrzA binds to mWnt-8 in cell culture experiments [3].

References