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Gene Review

Hml  -  Hemolectin

Drosophila melanogaster

Synonyms: CG7002, CT21553, Dmel\CG7002, d-hml, hml
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High impact information on Hml

  • This rescue correlated with the overexpression of tsp68C, a tetraspanin gene nested in the hml promoter [1].
  • A hemolectin (hml)-Gal4 construct carried by hml-Gal4 transgenic flies was sufficient by itself to abrogate the hematopoietic defects in ytr mutant larvae [1].
  • After knockdown of fon by RNAi, bead aggregation activity of larval hemolymph is strongly reduced, and wound closure is affected. fon is thus the second Drosophila gene after hemolectin (hml), for which a knockdown causes a clotting phenotype [2].
  • By crossing hml-GAL4 with UAS-eGFP, we observed that Hml is specifically expressed in embryonic and in larval hemocytes [3].
  • Altogether, our data strongly suggest that Hml is involved in hemostasis and/or coagulation in Drosophila larvae [3].

Biological context of Hml


Anatomical context of Hml

  • We have previously identified and characterized Drosophila hemolectin (Hml) in the conditioned medium of a Drosophila cell line [3].

Analytical, diagnostic and therapeutic context of Hml


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