Disease relevance of RCJMB04_6f14

• To identify the genes directly responsible, through DNA polymorphism, for the difference in fatness observed between a lean and a fat chicken line, we studied five genes (ACL, ACC, FAS, ME, SCD1) encoding key enzymes involved in liver fatty acid synthesis and secretion [1].

High impact information on RCJMB04_6f14

• Hepatic expression of sterol regulatory element binding protein-1, ATP-citrate lyase, fatty acid synthase, malic enzyme, acetyl-CoA carboxylase and stearoyl-CoA (Delta9) desaturase 1 genes in ad libitum birds declined from their highest levels just before photostimulation as the birds came into and maintained egg production [2].
• Hepatic activities of malate dehydrogenase [EC 1.1.1.40 (MD)] and ATP citrate lyase [EC 4.1.3.8 (CL)] were correlated with the proportion of both abdominal and total body fat (r = 0.50) but were poorly correlated with gain: food ratio [3].
• 2. There were no marked effects of excess biotin on glutamate-metabolising enzymes but the specific activity of ATP citrate lyase was decreased [4].
• 1. Increases in hepatic ATP citrate lyase specific activity and in serum thyroxine levels were observed in immature chicks in response to either controlled food and water intakes at 22 degrees C, or an elevation in environmental temperature to 30 degrees C. Hepatic phosphofructokinase specific activity was reduced at the higher temperature [5].

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