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Gene Review:

Meics - Meiotic central spindle

Drosophila melanogaster

Synonyms: CG8474, Dmel\CG8474

Guais, A. et al., Jang, J.K. et al., Panzera, Y. et al., Bouchard, M.L. et al.

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High impact information on Meics

Subito encodes a kinesinlike protein and associates with the meiotic central spindle, consistent with its classification in the Kinesin 6/MKLP1 family [1].
The meiotic central spindle appears during prometaphase and includes passenger complex proteins such as AurB and Incenp [1].
In Drosophila, the RING finger protein d-Goliath was originally identified as a transcription factor involved in the embryo mesoderm formation [Bouchard, M.L., Cote, S., 1993. The Drosophila melanogaster developmental gene g1 encodes a variant zinc-finger-motif protein. Gene 125, 205-209] [2].
A Drosophila gene encoding a novel zinc-finger protein, Meics, was cloned using a monoclonal antibody [3].
During spermatogenesis, Meics distributes intranuclearly at pre- and post-meiotic stages whereas it relocates to central-spindle microtubules at both meiotic divisions [3].

Biological context of Meics

The Drosophila melanogaster developmental gene g1 encodes a variant zinc-finger-motif protein [4].

References

The kinesinlike protein Subito contributes to central spindle assembly and organization of the meiotic spindle in Drosophila oocytes. Jang, J.K., Rahman, T., McKim, K.S. Mol. Biol. Cell (2005) [Pubmed]
h-Goliath, paralog of GRAIL, is a new E3 ligase protein, expressed in human leukocytes. Guais, A., Siegrist, S., Solhonne, B., Jouault, H., Guellaën, G., Bulle, F. Gene (2006) [Pubmed]
Meics, a novel zinc-finger protein which relocates from nuclei to the central meiotic spindle during Drosophila spermatogenesis. Panzera, Y., Esteban, M.R., de la Hera, A., Goday, C. Mech. Dev. (2001) [Pubmed]
The Drosophila melanogaster developmental gene g1 encodes a variant zinc-finger-motif protein. Bouchard, M.L., Côté, S. Gene (1993) [Pubmed]

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