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Gene Review:

Incenp - Inner centromere protein

Drosophila melanogaster

Synonyms: CG12165, DmINCENP, Dmel\CG12165, INCENP, anon-WO0118547.171, ...

Adams, R.R. et al., Resnick, T.D. et al., Jang, J.K. et al., Tseng, A.S. et al., Parry, D.H. et al., et al.

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High impact information on Incenp

These experiments reveal that INCENP is required for aurora B kinase function and confirm that the chromosomal passengers have essential roles in mitosis [1].
DmAurora B is required for DmINCENP accumulation at centromeres and transfer to the spindle at anaphase [1].
The two proteins bind to each other in vitro, and DmINCENP is required for DmAurora B to localize properly in mitosis and function as a histone H3 kinase [1].
We have performed a biochemical and double-stranded RNA-mediated interference (RNAi) analysis of the role of two chromosomal passenger proteins, inner centromere protein (INCENP) and aurora B kinase, in cultured cells of Drosophila melanogaster [1].
DmINCENP and DmAurora B are not required for the correct localization of the kinesin-like protein Pavarotti (ZEN-4/CHO1/MKLP1) to the midbody at telophase [1].

Biological context of Incenp

Drosophila Incenp is required for cytokinesis and asymmetric cell division during development of the nervous system [2].
The meiotic central spindle appears during prometaphase and includes passenger complex proteins such as AurB and Incenp [3].
The dynamics of the chromosome passenger protein, INCENP, are affected after Drad21 depletion [4].
Finally, the normal anaphase release of AuroraB/INCENP from kinetochores was blocked by CYC-B(S) expression and, reciprocally, was advanced in a CycB mutant [5].
Lines with insertions near INCENP, elB, and CG11518 were characterized in more detail with respect to changes in growth, cell-cycle phasing, and doubling times that were elicited by overexpression [6].

Physical interactions of Incenp

INCENP binds to the cohesion protector protein MEI-S332, which is also an excellent in vitro substrate for Aurora B kinase [7].

Other interactions of Incenp

In the absence of Subito, central spindle formation is defective and AurB and Incenp fail to properly localize [3].
INCENP and Aurora B promote meiotic sister chromatid cohesion through localization of the Shugoshin MEI-S332 in Drosophila [7].

References

Essential roles of Drosophila inner centromere protein (INCENP) and aurora B in histone H3 phosphorylation, metaphase chromosome alignment, kinetochore disjunction, and chromosome segregation. Adams, R.R., Maiato, H., Earnshaw, W.C., Carmena, M. J. Cell Biol. (2001) [Pubmed]
Drosophila Incenp is required for cytokinesis and asymmetric cell division during development of the nervous system. Chang, C.J., Goulding, S., Adams, R.R., Earnshaw, W.C., Carmena, M. J. Cell. Sci. (2006) [Pubmed]
The kinesinlike protein Subito contributes to central spindle assembly and organization of the meiotic spindle in Drosophila oocytes. Jang, J.K., Rahman, T., McKim, K.S. Mol. Biol. Cell (2005) [Pubmed]
Depletion of Drad21/Scc1 in Drosophila cells leads to instability of the cohesin complex and disruption of mitotic progression. Vass, S., Cotterill, S., Valdeolmillos, A.M., Barbero, J.L., Lin, E., Warren, W.D., Heck, M.M. Curr. Biol. (2003) [Pubmed]
Cyclin B destruction triggers changes in kinetochore behavior essential for successful anaphase. Parry, D.H., Hickson, G.R., O'Farrell, P.H. Curr. Biol. (2003) [Pubmed]
An overexpression screen in Drosophila for genes that restrict growth or cell-cycle progression in the developing eye. Tseng, A.S., Hariharan, I.K. Genetics (2002) [Pubmed]
INCENP and Aurora B promote meiotic sister chromatid cohesion through localization of the Shugoshin MEI-S332 in Drosophila. Resnick, T.D., Satinover, D.L., MacIsaac, F., Stukenberg, P.T., Earnshaw, W.C., Orr-Weaver, T.L., Carmena, M. Dev. Cell (2006) [Pubmed]

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