Disease relevance of SHC

• Insulin receptor substrate 1 antisense expression in an hepatoma cell line reduces cell proliferation and induces overexpression of the Src homology 2 domain and collagen protein (SHC) [1].

High impact information on SHC

• Transformation and pp60v-src autophosphorylation correlate with SHC-GRB2 complex formation in rat and chicken cells expressing host-range and kinase-active, transformation-defective alleles of v-src [2].
• In wild type LMH cells, SHC which is involved in Ras pathway, also served as a substrate for insulin receptor tyrosine kinase [1].
• In C2 cells, SHC expression, its association with the insulin receptor and its tyrosine phosphorylation were largely increased [1].
• Instead, there is a continuous change between the extreme forms (tall hair cells = THC, and short hair cells = SHC) [3].
• The lack of afferent innervation indicates that the function of basal SHC is restricted to the basilar papilla itself, perhaps modifying its mechanical properties [3].

Biological context of SHC

• Furthermore, association of phosphorylated SHC with the adapter GRB2 correlated with increased anchorage-independent growth (and autophosphorylation) in both rat and chicken cells independent of the morphological phenotype induced [2].

Anatomical context of SHC

• The hair-cell innervation pattern is complicated, there being no simple gradient between THC (mainly innervated by afferent fibers) and SHC (mainly innervated by efferent fibers) [3].

References