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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Organ of Corti

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Disease relevance of Organ of Corti


High impact information on Organ of Corti


Chemical compound and disease context of Organ of Corti


Biological context of Organ of Corti


Anatomical context of Organ of Corti

  • Organization of AMPA receptor subunits at a glutamate synapse: a quantitative immunogold analysis of hair cell synapses in the rat organ of Corti [19].
  • Loss of Barhl1 function in mice results in age-related progressive degeneration of both outer and inner hair cells in the organ of Corti, following two reciprocal longitudinal gradients [20].
  • Whole mounts double-labeled with antibodies to the 275 kDa hair-cell antigen and the tight junction protein cingulin were therefore used to examine the development of cell patterns in the basilar papilla [21].
  • Histological analysis of the cerebellum and inner ear of mutant and wild-type mice revealed that null mutants had slightly increased numbers of Purkinje neurons (in which PMCA2 is highly expressed), a decreased thickness of the molecular layer, an absence of otoconia in the vestibular system, and a range of abnormalities of the organ of Corti [22].
  • Centrosomal reorganization in the cells in question, outer pillar cells of the organ of Corti, indicates that its pericentriolar material becomes intimately associated with the plasma membrane at the two nucleating sites [23].

Associations of Organ of Corti with chemical compounds


Gene context of Organ of Corti

  • In this sensory system, aFGF, rather than being a neurotrophic factor, seems to promote maintenance of the integrity of the organ of Corti [14].
  • The mouse slalom mutant demonstrates a role for Jagged1 in neuroepithelial patterning in the organ of Corti [29].
  • Here, we show that Islet1 (Isl1), a LIM-HD protein, is expressed early in the otocyst in the region that gives rise to both the auditory sensory organ, the organ of Corti, and SG neurons [30].
  • Expression of alpha and beta parvalbumin is differentially regulated in the rat organ of corti during development [31].
  • The organ of Corti showed an enhanced in situ labeling with RARalpha and RXRbeta [32].

Analytical, diagnostic and therapeutic context of Organ of Corti


  1. Comparison of toluene-induced and styrene-induced hearing losses. Loquet, G., Campo, P., Lataye, R. Neurotoxicology and teratology. (1999) [Pubmed]
  2. Ultrastructural changes in the organ of Corti and in the ganglion spiral cochleae after vitamin A deficiency. Löhle, E. Pathol. Res. Pract. (1985) [Pubmed]
  3. Use of organotypic cultures of Corti's organ to study the protective effects of antioxidant molecules on cisplatin-induced damage of auditory hair cells. Kopke, R.D., Liu, W., Gabaizadeh, R., Jacono, A., Feghali, J., Spray, D., Garcia, P., Steinman, H., Malgrange, B., Ruben, R.J., Rybak, L., Van de Water, T.R. The American journal of otology. (1997) [Pubmed]
  4. Maturational and degenerative processes in the organ of Corti after neonatal hypothyroidism. Uziel, A., Legrand, C., Ohresser, M., Marot, M. Hear. Res. (1983) [Pubmed]
  5. Expression of prestin mRNA in the organotypic culture of rat cochlea. Gross, J., Machulik, A., Amarjargal, N., Fuchs, J., Mazurek, B. Hear. Res. (2005) [Pubmed]
  6. Impaired permeability to Ins(1,4,5)P3 in a mutant connexin underlies recessive hereditary deafness. Beltramello, M., Piazza, V., Bukauskas, F.F., Pozzan, T., Mammano, F. Nat. Cell Biol. (2005) [Pubmed]
  7. FGFR1 is required for the development of the auditory sensory epithelium. Pirvola, U., Ylikoski, J., Trokovic, R., Hébert, J.M., McConnell, S.K., Partanen, J. Neuron (2002) [Pubmed]
  8. Distribution of Ca2+-activated K+ channel isoforms along the tonotopic gradient of the chicken's cochlea. Rosenblatt, K.P., Sun, Z.P., Heller, S., Hudspeth, A.J. Neuron (1997) [Pubmed]
  9. Human nonsyndromic hereditary deafness DFNA17 is due to a mutation in nonmuscle myosin MYH9. Lalwani, A.K., Goldstein, J.A., Kelley, M.J., Luxford, W., Castelein, C.M., Mhatre, A.N. Am. J. Hum. Genet. (2000) [Pubmed]
  10. Gene disruption of p27(Kip1) allows cell proliferation in the postnatal and adult organ of corti. Löwenheim, H., Furness, D.N., Kil, J., Zinn, C., Gültig, K., Fero, M.L., Frost, D., Gummer, A.W., Roberts, J.M., Rubel, E.W., Hackney, C.M., Zenner, H.P. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  11. The role of thyroxine in the differentiation of the organ of Corti. Deol, M.S. Acta Otolaryngol. (1976) [Pubmed]
  12. The use of intravenous lignocaine in the diagnosis and treatment of tinnitus. Melding, P.S., Goodey, R.J., Thorne, P.R. The Journal of laryngology and otology. (1978) [Pubmed]
  13. Round window application of D-methionine provides complete cisplatin otoprotection. Korver, K.D., Rybak, L.P., Whitworth, C., Campbell, K.M. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. (2002) [Pubmed]
  14. The site of action of neuronal acidic fibroblast growth factor is the organ of Corti of the rat cochlea. Pirvola, U., Cao, Y., Oellig, C., Suoqiang, Z., Pettersson, R.F., Ylikoski, J. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  15. Mutations in the transcriptional activator EYA4 cause late-onset deafness at the DFNA10 locus. Wayne, S., Robertson, N.G., DeClau, F., Chen, N., Verhoeven, K., Prasad, S., Tranebjärg, L., Morton, C.C., Ryan, A.F., Van Camp, G., Smith, R.J. Hum. Mol. Genet. (2001) [Pubmed]
  16. Identification of the timing of S phase and the patterns of cell proliferation during hair cell regeneration in the chick cochlea. Stone, J.S., Cotanche, D.A. J. Comp. Neurol. (1994) [Pubmed]
  17. Human inner ear OCP2 cDNA maps to 5q22-5q35.2 with related sequences on chromosomes 4p16.2-4p14, 5p13-5q22, 7pter-q22, 10 and 12p13-12qter. Liang, Y., Chen, H., Asher, J.H., Chang, C.C., Friedman, T.B. Gene (1997) [Pubmed]
  18. SNARE complex at the ribbon synapses of cochlear hair cells: analysis of synaptic vesicle- and synaptic membrane-associated proteins. Safieddine, S., Wenthold, R.J. Eur. J. Neurosci. (1999) [Pubmed]
  19. Organization of AMPA receptor subunits at a glutamate synapse: a quantitative immunogold analysis of hair cell synapses in the rat organ of Corti. Matsubara, A., Laake, J.H., Davanger, S., Usami, S., Ottersen, O.P. J. Neurosci. (1996) [Pubmed]
  20. Hearing loss caused by progressive degeneration of cochlear hair cells in mice deficient for the Barhl1 homeobox gene. Li, S., Price, S.M., Cahill, H., Ryugo, D.K., Shen, M.M., Xiang, M. Development (2002) [Pubmed]
  21. Pattern formation in the basilar papilla: evidence for cell rearrangement. Goodyear, R., Richardson, G. J. Neurosci. (1997) [Pubmed]
  22. Balance and hearing deficits in mice with a null mutation in the gene encoding plasma membrane Ca2+-ATPase isoform 2. Kozel, P.J., Friedman, R.A., Erway, L.C., Yamoah, E.N., Liu, L.H., Riddle, T., Duffy, J.J., Doetschman, T., Miller, M.L., Cardell, E.L., Shull, G.E. J. Biol. Chem. (1998) [Pubmed]
  23. Formation of two microtubule-nucleating sites which perform differently during centrosomal reorganization in a mouse cochlear epithelial cell. Tucker, J.B., Mogensen, M.M., Paton, C.C., Mackie, J.B., Henderson, C.G., Leckie, L.M. J. Cell. Sci. (1995) [Pubmed]
  24. The developing organ of Corti contains retinoic acid and forms supernumerary hair cells in response to exogenous retinoic acid in culture. Kelley, M.W., Xu, X.M., Wagner, M.A., Warchol, M.E., Corwin, J.T. Development (1993) [Pubmed]
  25. Ototoxicity caused by cisplatin is ameliorated by melatonin and other antioxidants. Lopez-Gonzalez, M.A., Guerrero, J.M., Rojas, F., Delgado, F. J. Pineal Res. (2000) [Pubmed]
  26. Basic fibroblast growth factor (FGF-2) protects rat cochlear hair cells in organotypical culture from aminoglycoside injury. Low, W., Dazert, S., Baird, A., Ryan, A.F. J. Cell. Physiol. (1996) [Pubmed]
  27. Audiogenic seizures and cochlear damage in rats after perinatal antithyroid treatment. Van Middlesworth, L., Norris, C.H. Endocrinology (1980) [Pubmed]
  28. Facilitating efferent inhibition of inner hair cells in the cochlea of the neonatal rat. Goutman, J.D., Fuchs, P.A., Glowatzki, E. J. Physiol. (Lond.) (2005) [Pubmed]
  29. The mouse slalom mutant demonstrates a role for Jagged1 in neuroepithelial patterning in the organ of Corti. Tsai, H., Hardisty, R.E., Rhodes, C., Kiernan, A.E., Roby, P., Tymowska-Lalanne, Z., Mburu, P., Rastan, S., Hunter, A.J., Brown, S.D., Steel, K.P. Hum. Mol. Genet. (2001) [Pubmed]
  30. Expression of Islet1 marks the sensory and neuronal lineages in the mammalian inner ear. Radde-Gallwitz, K., Pan, L., Gan, L., Lin, X., Segil, N., Chen, P. J. Comp. Neurol. (2004) [Pubmed]
  31. Expression of alpha and beta parvalbumin is differentially regulated in the rat organ of corti during development. Yang, D., Thalmann, I., Thalmann, R., Simmons, D.D. J. Neurobiol. (2004) [Pubmed]
  32. Spatial distributions of retinoic acid receptor gene transcripts in the prenatal mouse inner ear. Romand, R., Sapin, V., Dollé, P. J. Comp. Neurol. (1998) [Pubmed]
  33. Electron microscopy of degenerative changes in the chick basilar papilla after gentamicin exposure. Hirose, K., Westrum, L.E., Cunningham, D.E., Rubel, E.W. J. Comp. Neurol. (2004) [Pubmed]
  34. Dopaminergic lateral efferent innervation of the guinea-pig cochlea: immunoelectron microscopy of catecholamine-synthesizing enzymes and effect of 6-hydroxydopamine. Eybalin, M., Charachon, G., Renard, N. Neuroscience (1993) [Pubmed]
  35. Tissue-specific levels and cellular distribution of epidermal growth factor receptors within control and neomycin-damaged neonatal rat Organ of Corti. Zine, A., de Ribaupierre, F. J. Neurobiol. (1999) [Pubmed]
  36. Several distinct receptor binding enkephalins in olivocochlear fibers and terminals in the organ of Corti. Hoffman, D.W., Rubio, J.A., Altschuler, R.A., Fex, J. Brain Res. (1984) [Pubmed]
  37. Choline acetyltransferase (ChAT) immunoelectron microscopy distinguishes at least three types of efferent synapses in the organ of Corti. Eybalin, M., Pujol, R. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (1987) [Pubmed]
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