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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

TIMP3  -  TIMP metallopeptidase inhibitor 3

Gallus gallus

 
 
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High impact information on TIMP3

  • Role of the 21-kDa protein TIMP-3 in oncogenic transformation of cultured chicken embryo fibroblasts [1].
  • The cDNA of the 21-kDa protein was recently cloned, and based upon its deduced amino acid sequence and other supporting data we propose that it is another member of this family, a TIMP-3 [1].
  • TIMP-3 mRNA is expressed only in the notochord at stage 8 and later in the outflow tract myocardium [2].
  • Here, we examine the distribution of tissue inhibitor of metalloproteinase (TIMP) -2 and TIMP-3 and test whether manipulating TIMP levels alters chicken cardiac NC cell migration [2].
  • Upon hybridization with a panel of human-hamster somatic cell hybrid DNAs, the TIMP3 gene segregated with clones containing chromosome 22 [3].
 

Other interactions of TIMP3

 

Analytical, diagnostic and therapeutic context of TIMP3

References

  1. Role of the 21-kDa protein TIMP-3 in oncogenic transformation of cultured chicken embryo fibroblasts. Yang, T.T., Hawkes, S.P. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  2. Tissue inhibitor of metalloproteinase-2 (TIMP-2) expression during cardiac neural crest cell migration and its role in proMMP-2 activation. Cantemir, V., Cai, D.H., Reedy, M.V., Brauer, P.R. Dev. Dyn. (2004) [Pubmed]
  3. Cloning of the cDNA encoding human tissue inhibitor of metalloproteinases-3 (TIMP-3) and mapping of the TIMP3 gene to chromosome 22. Apte, S.S., Mattei, M.G., Olsen, B.R. Genomics (1994) [Pubmed]
  4. Mapping the ABCA4, IMPDH2 and TIMP3 genes in chicken. Paton, I.R., Smith, J., Burt, D.W. Anim. Genet. (2003) [Pubmed]
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