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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

TIMP3  -  TIMP metallopeptidase inhibitor 3

Macaca mulatta

 
 
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High impact information on TIMP3

  • TIMP-3 mRNA in the endometrium was specifically localized to some cells lining the outer membrane of several groups of arterioles [1].
  • Studies were designed to determine if ADAMTS-1 (a disintegrin and metalloproteinase with thrombospondin repeats-1) is expressed in the rhesus monkey corpus luteum (CL), is regulated by endocrine (LH) or local (progesterone) factors, and is correlated with tissue inhibitor of matrix metalloproteinase-3 (TIMP-3), an inhibitor of ADAMTS-1 [2].
  • ADAMTS-1/METH-1 and TIMP-3 expression in the primate corpus luteum: divergent patterns and stage-dependent regulation during the natural menstrual cycle [2].
  • We have examined the expression of MMP-2, TIMP-1, and TIMP-3 mRNA at the implantation site of rhesus monkeys during early stage of pregnancy using in situ hybridization and Northern blot analysis [3].
  • Therefore, TIMP-3 may be the main inhibitor that restricts the trophoblast invasion [3].

References

  1. Expression of matrix metalloproteinase-2, -9, -14, and tissue inhibitors of metalloproteinase-1, -2, -3 in the endometrium and placenta of rhesus monkey (Macaca mulatta) during early pregnancy. Wang, H., Li, Q., Shao, L., Zhu, C. Biol. Reprod. (2001) [Pubmed]
  2. ADAMTS-1/METH-1 and TIMP-3 expression in the primate corpus luteum: divergent patterns and stage-dependent regulation during the natural menstrual cycle. Young, K.A., Tumlinson, B., Stouffer, R.L. Mol. Hum. Reprod. (2004) [Pubmed]
  3. Expression of matrix metalloproteinase-2, tissue inhibitors of metalloproteinase-1, -3 at the implantation site of rhesus monkey during the early stage of pregnancy. Gao, F., Chen, X.L., Wei, P., Gao, H.J., Liu, Y.X. Endocrine (2001) [Pubmed]
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