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Gene Review

TIMP3  -  TIMP metallopeptidase inhibitor 3

Macaca mulatta

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High impact information on TIMP3

  • TIMP-3 mRNA in the endometrium was specifically localized to some cells lining the outer membrane of several groups of arterioles [1].
  • Studies were designed to determine if ADAMTS-1 (a disintegrin and metalloproteinase with thrombospondin repeats-1) is expressed in the rhesus monkey corpus luteum (CL), is regulated by endocrine (LH) or local (progesterone) factors, and is correlated with tissue inhibitor of matrix metalloproteinase-3 (TIMP-3), an inhibitor of ADAMTS-1 [2].
  • ADAMTS-1/METH-1 and TIMP-3 expression in the primate corpus luteum: divergent patterns and stage-dependent regulation during the natural menstrual cycle [2].
  • We have examined the expression of MMP-2, TIMP-1, and TIMP-3 mRNA at the implantation site of rhesus monkeys during early stage of pregnancy using in situ hybridization and Northern blot analysis [3].
  • Therefore, TIMP-3 may be the main inhibitor that restricts the trophoblast invasion [3].


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