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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

GJA5  -  gap junction protein, alpha 5, 40kDa

Gallus gallus

 
 
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High impact information on GJA5

  • Chick connexin-45 has a predicted molecular mass of 45,376 daltons; connexin-42 has a predicted molecular mass of 41,748 daltons [1].
  • Blots of total RNA isolated from hearts of chick embryos of different ages demonstrate that the abundance of connexin-42 and -43 mRNAs varies no more than 2-fold between the embryo and the adult [1].
  • Thus, Cx42 gap junctions may be involved in specification of the arterial vasculature of the limb and embryo [2].
  • We have examined the expression patterns of two members of the connexin family, connexin43 (Cx43) and connexin42 (Cx42), during the early development of the chick limb bud and embryo by in situ hybridization [2].
  • Cx42, but not Cx43, is expressed in the ventricle of the heart, and by cells along the intrasclerotomal fissure that separates the rostral and caudal halves of the sclerotome of somites into distinct communication compartments [2].
 

Biological context of GJA5

  • The spatial and temporal expression of three closely related members of the connexin family of gap junction proteins (connexin42, Cx42; connexin43, Cx43; and connexin45, Cx45) was evaluated during bone formation in the mandibular process of the chick embryo [3].

References

  1. Molecular cloning and developmental expression of two chick embryo gap junction proteins. Beyer, E.C. J. Biol. Chem. (1990) [Pubmed]
  2. Expression patterns of mRNAs for the gap junction proteins connexin43 and connexin42 suggest their involvement in chick limb morphogenesis and specification of the arterial vasculature. Dealy, C.N., Beyer, E.C., Kosher, R.A. Dev. Dyn. (1994) [Pubmed]
  3. Gap junction proteins exhibit early and specific expression during intramembranous bone formation in the developing chick mandible. Minkoff, R., Rundus, V.R., Parker, S.B., Hertzberg, E.L., Laing, J.G., Beyer, E.C. Anat. Embryol. (1994) [Pubmed]
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