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Gene Review

SCP2  -  sterol carrier protein 2

Gallus gallus

Synonyms: NSL-TP, SCP-2, SCP-X, SCPX
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High impact information on SCP2

  • A reduction in SCP2/SCPx gene expression was observed with follicular maturation, correlating with falling estrogen production [1].
  • The two SCP2/SCPx mRNAs were most abundant in granulosa cells from small follicles [1].
  • The 2.4-kb clone, isolated from a liver cDNA library by homology screening with a rat SCP2 cDNA, encodes a 58-kDa polypeptide, SCPx, which encompasses the sequence for SCP2 at its C-terminus [1].
  • In summary, we have documented (i) marked conservation of SCP2/SCPx structure across species and (ii) developmental and hormonal regulation of the mRNAs which encode proteins thought to be involved in lipid metabolism [1].
  • Sterol Carrier Protein 2, a protein thought to be involved in various aspects of intracellular sterol transport and metabolism, was studied in the small intestine and liver of chickens near hatching [2].

Analytical, diagnostic and therapeutic context of SCP2

  • Northern blot analysis of poly(A)+ RNA from different chicken tissues revealed two mRNA species, one of 2.5 kb, encoding SCPx, and one of 1.4 kb, presumably encoding SCP2 [1].


  1. Chicken sterol carrier protein 2/sterol carrier protein x: cDNA cloning reveals evolutionary conservation of structure and regulated expression. Pfeifer, S.M., Sakuragi, N., Ryan, A., Johnson, A.L., Deeley, R.G., Billheimer, J.T., Baker, M.E., Strauss, J.F. Arch. Biochem. Biophys. (1993) [Pubmed]
  2. Developmental regulation of sterol carrier protein 2 in chicken intestine and liver at time of hatching. Reinhart, M.P., Foglia, T.A., Cooke, P.H. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
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