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Gene Review

Scp2  -  sterol carrier protein 2

Rattus norvegicus

Synonyms: NSL-TP, NSLIPTR, Non-specific lipid-transfer protein, Propanoyl-CoA C-acyltransferase, SCP-2, ...
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Disease relevance of Scp2


High impact information on Scp2


Biological context of Scp2


Anatomical context of Scp2


Associations of Scp2 with chemical compounds

  • Each of the genes Scp2, Sqle and Fdft1 maps close to a QTL for serum total cholesterol in rat, suggesting that these three genes might represent candidate genes for the previously mapped QTLs [14].
  • Rats (Day 3 pregnant) received an injection of streptozotocin (STZ, 60 mg/kg; i.v.) to induce a diabetic state; P450scc, 3 beta-HSD, and SCP2 were examined by Western and Northern blot analysis in ovarian tissue 12 days after injection of STZ (diabetic rats, n = 12) or vehicle (nondiabetic rats, n = 12) [10].
  • Increased SCPx expression coincided with increased serum triglyceride and beta-HBA levels, suggesting that the enhanced SCPx level may coincide with an ovarian shift to fatty acid metabolism [10].
  • The C-terminal sequence of SCPx is identical to SCP2, while its N-terminal region is homologous with 3-oxoacyl coenzyme A thiolase, an enzyme involved in fatty acid metabolism [10].
  • The amino acid sequence of Sterol Carrier Protein2 (SCP2) isolated from rat has been investigated [15].

Physical interactions of Scp2


Other interactions of Scp2


Analytical, diagnostic and therapeutic context of Scp2

  • Restriction mapping and nucleotide sequencing analyses of these cDNAs indicate that eight extend upstream of the SCP2 cDNA, and two extend 5' as well as 3'. Translation of the sequence extending most upstream suggests that this cDNA is a nearly full-length cDNA coding for a protein of 547 amino acids (SCP chi) [6].
  • Consistent with the loss of SCP2 mRNA expression, Western blot analysis indicated that a 15-kilodalton SCP2-immunoreactive protein (presumably the pro-SCP2 form) was significantly reduced or absent in the PGF2 alpha treated animals (P < 0.04).(ABSTRACT TRUNCATED AT 400 WORDS)[9]
  • The production of cholic acid and chenodeoxycholic acid from the precursors on incubation with the bifunctional protein and sterol carrier protein x or P-44 was confirmed by gas chromatography [18].
  • The occurrence and subcellular distribution of the non-specific lipid transfer protein (nsL-TP; sterol carrier protein 2) in rat tissues was investigated by the immunoblotting technique using the affinity purified antibody against rat liver nsL-TP [19].
  • By gel chromatography, enzyme immunoassay and immunoblotting it was demonstrated that the activity in the wash was due to the nonspecific lipid transfer protein (sterol carrier protein 2) [20].


  1. Elevated cholesterol and decreased sterol carrier protein-2 in peroxisomes from AS-30D hepatoma compared to normal rat liver. Lyons, H.T., Kharroubi, A., Wolins, N., Tenner, S., Chanderbhan, R.F., Fiskum, G., Donaldson, R.P. Arch. Biochem. Biophys. (1991) [Pubmed]
  2. Subcellular localization of sterol carrier protein-2 in rat hepatocytes: its primary localization to peroxisomes. Keller, G.A., Scallen, T.J., Clarke, D., Maher, P.A., Krisans, S.K., Singer, S.J. J. Cell Biol. (1989) [Pubmed]
  3. Molecular cloning and deduced amino acid sequence of nonspecific lipid transfer protein (sterol carrier protein 2) of rat liver: a higher molecular mass (60 kDa) protein contains the primary sequence of nonspecific lipid transfer protein as its C-terminal part. Mori, T., Tsukamoto, T., Mori, H., Tashiro, Y., Fujiki, Y. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  4. Sterol carrier protein-2 overexpression enhances sterol cycling and inhibits cholesterol ester synthesis and high density lipoprotein cholesterol secretion. Baum, C.L., Reschly, E.J., Gayen, A.K., Groh, M.E., Schadick, K. J. Biol. Chem. (1997) [Pubmed]
  5. Substrate specificities of 3-oxoacyl-CoA thiolase A and sterol carrier protein 2/3-oxoacyl-CoA thiolase purified from normal rat liver peroxisomes. Sterol carrier protein 2/3-oxoacyl-CoA thiolase is involved in the metabolism of 2-methyl-branched fatty acids and bile acid intermediates. Antonenkov, V.D., Van Veldhoven, P.P., Waelkens, E., Mannaerts, G.P. J. Biol. Chem. (1997) [Pubmed]
  6. Cloning, expression, and nucleotide sequence of rat liver sterol carrier protein 2 cDNAs. Seedorf, U., Assmann, G. J. Biol. Chem. (1991) [Pubmed]
  7. Phospholipid-transfer proteins and their mRNAs in developing rat lung and in alveolar type-II cells. Batenburg, J.J., Ossendorp, B.C., Snoek, G.T., Wirtz, K.W., Houweling, M., Elfring, R.H. Biochem. J. (1994) [Pubmed]
  8. Protein kinase C catalyzed phosphorylation of sterol carrier protein 2. Steinschneider, A., McLean, M.P., Billheimer, J.T., Azhar, S., Gibori, G. Endocrinology (1989) [Pubmed]
  9. Prostaglandin F2 alpha mediates ovarian sterol carrier protein-2 expression during luteolysis. McLean, M.P., Billheimer, J.T., Warden, K.J., Irby, R.B. Endocrinology (1995) [Pubmed]
  10. Altered ovarian sterol carrier protein expression in the pregnant streptozotocin-treated diabetic rat. McLean, M.P., Warden, K.J., Sandhoff, T.W., Irby, R.B., Hales, D.B. Biol. Reprod. (1996) [Pubmed]
  11. Neurosteroids and female reproduction: estrogen increases 3beta-HSD mRNA and activity in rat hypothalamus. Soma, K.K., Sinchak, K., Lakhter, A., Schlinger, B.A., Micevych, P.E. Endocrinology (2005) [Pubmed]
  12. Peroxisome proliferator-activated receptor alpha induces rat sterol carrier protein x promoter activity through two peroxisome proliferator-response elements. Lopez, D., Irby, R.B., McLean, M.P. Mol. Cell. Endocrinol. (2003) [Pubmed]
  13. Sterol carrier protein X is peroxisomal 3-oxoacyl coenzyme A thiolase with intrinsic sterol carrier and lipid transfer activity. Seedorf, U., Brysch, P., Engel, T., Schrage, K., Assmann, G. J. Biol. Chem. (1994) [Pubmed]
  14. Chromosomal localization of genes involved in biosynthesis, metabolism or transport of cholesterol in the rat. Bonné, A.C., den Bieman, M.G., Gillissen, G.F., van Lith, H.A., van Zutphen, L.F. Cytogenet. Genome Res. (2002) [Pubmed]
  15. A mass spectrometric study of the structure of sterol carrier protein SCP2 from rat liver. Morris, H.R., Larsen, B.S., Billheimer, J.T. Biochem. Biophys. Res. Commun. (1988) [Pubmed]
  16. Characterization of a steroidogenic factor-1-binding site found in promoter of sterol carrier protein-2 gene. Lopez, D., Shea-Eaton, W., McLean, M.P. Endocrine (2001) [Pubmed]
  17. Leydig cell peroxisomes and sterol carrier protein-2 in luteinizing hormone-deprived rats. Mendis-Handagama, S.M., Watkins, P.A., Gelber, S.J., Scallen, T.J. Endocrinology (1992) [Pubmed]
  18. Thiolase involved in bile acid formation. Bun-ya, M., Maebuchi, M., Kamiryo, T., Kurosawa, T., Sato, M., Tohma, M., Jiang, L.L., Hashimoto, T. J. Biochem. (1998) [Pubmed]
  19. The occurrence of soluble and membrane-bound non-specific lipid transfer protein (sterol carrier protein 2) in rat tissues. Van Heusden, G.P., Bos, K., Wirtz, K.W. Biochim. Biophys. Acta (1990) [Pubmed]
  20. Nonspecific lipid transfer protein (sterol carrier protein 2) is bound to rat liver mitochondria: its role in spontaneous intermembrane phospholipid transfer. Megli, F.M., De Lisi, A., van Amerongen, A., Wirtz, K.W., Quagliariello, E. Biochim. Biophys. Acta (1986) [Pubmed]
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