Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

UCP2 - uncoupling protein 2 (mitochondrial,...

Sus scrofa

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of UCP2

This study examined whether birth weight influences the expression of UCP2 and UCP3 in adipose tissue, skeletal muscle, and lung [1].

High impact information on UCP2

Uncoupling protein 2 expression is enhanced in the mitochondria, providing a potential mechanism for these favorable mitochondrial adaptations [2].
Lung UCP2 and skeletal muscle UCP3 mRNA expression were unaffected by size at birth [1].
UCP2 and UCP3 expression in adipose tissue was lower in the SFD compared with the LFD group on day 7 [1].
Plasma hormone and metabolite concentrations and the expression of UCP2 and UCP3 mRNA in adipose tissue, skeletal muscle, and lung were measured [1].
UCP2 protein abundance in AT was similar between genotypes on the first day of life, but it was elevated at all subsequent postnatal ages (P<0.05) in AT of Meishan piglets [3].

Biological context of UCP2

Characterization of the porcine uncoupling proteins 2 and 3 (UCP2 & UCP3) and their localization to chromosome 9 p by somatic cell hybrids [4].

Anatomical context of UCP2

This study was performed to determine whether or not uncoupling protein 2 (UCP2) and UCP3 expression in porcine subcutaneous adipose tissue are hormonally regulated in vitro and whether their expression is correlated with changes in metabolic activity [5].

Regulatory relationships of UCP2

Expression of UCP2 was induced by leptin (100 ng/mL; P<0.05) [5].
Growth hormone (100 ng/mL) inhibited UCP2 expression (P<0.05) [5].

Analytical, diagnostic and therapeutic context of UCP2

Expression of UCP2 and UCP3 was assessed in slices following 24h of incubation with various combinations of hormones by semi-quantitative RT-PCR [5].

References

Influence of size at birth on the endocrine profiles and expression of uncoupling proteins in subcutaneous adipose tissue, lung, and muscle of neonatal pigs. Mostyn, A., Litten, J.C., Perkins, K.S., Euden, P.J., Corson, A.M., Symonds, M.E., Clarke, L. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2005) [Pubmed]
Mitochondrial adaptations within chronically ischemic swine myocardium. McFalls, E.O., Sluiter, W., Schoonderwoerd, K., Manintveld, O.C., Lamers, J.M., Bezstarosti, K., van Beusekom, H.M., Sikora, J., Ward, H.B., Merkus, D., Duncker, D.J. J. Mol. Cell. Cardiol. (2006) [Pubmed]
Influence of genotype on the differential ontogeny of uncoupling protein 2 and 3 in subcutaneous adipose tissue and muscle in neonatal pigs. Mostyn, A., Litten, J.C., Perkins, K.S., Alves-Guerra, M.C., Pecqueur, C., Miroux, B., Symonds, M.E., Clarke, L. J. Endocrinol. (2004) [Pubmed]
Characterization of the porcine uncoupling proteins 2 and 3 (UCP2 & UCP3) and their localization to chromosome 9 p by somatic cell hybrids. Werner, P., Neuenschwander, S., Stranzinger, G. Anim. Genet. (1999) [Pubmed]
Regulation of uncoupling proteins 2 and 3 in porcine adipose tissue. Ramsay, T.G., Rosebrough, R.W. Domest. Anim. Endocrinol. (2005) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.