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Gene Review

LOC397711  -  BMP receptor

Xenopus laevis

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High impact information on LOC397711

  • Expression of this truncated BMP receptor during embryogenesis converts ventral mesoderm to dorsal mesoderm [1].
  • Phosphorylation by BMP receptor stimulates Smad1 transcriptional activity, whereas phosphorylation by MAPK has the opposite effect [2].
  • When coinjected with dominant-negative BMP receptor (tBR) in the ventral side of the embryo, XRhoA causes the formation of head structures resembling the phenotype seen after coinjection of wnt inhibitors with dominant-negative BMP receptor [3].
  • Conversely, reducing BMP signaling by expression of a dominant-negative BMP receptor or Noggin allows other animal blastomeres to contribute to the retina [4].
  • Since reporter activity obtained with distinct BMP-2/4 responsive promoter deletion mutants is simultaneously inhibited by the dominant negative BMP receptor as well as by chordin, we suggest that down-regulation of the BMP-4 gene by chordin results from an interference with the auto-regulatory loop at the level of protein-protein interactions [5].

Anatomical context of LOC397711


Associations of LOC397711 with chemical compounds

  • BMP signaling is mediated by specific Smad proteins, Smad1 and/or Smad5, which undergo serine phosphorylation in response to BMP-receptor activation and are then translocated to the nucleus where they modulate transcription of target genes [6].

Analytical, diagnostic and therapeutic context of LOC397711

  • RNAs were isolated from control animal cap explants and from dominant-negative BMP receptor expressing animal caps and subjected to a microarray experiment using newly generated high-density Xenopus DNA microarray chips representing over 17,000 unigenes [7].


  1. Studies with a Xenopus BMP receptor suggest that ventral mesoderm-inducing signals override dorsal signals in vivo. Graff, J.M., Thies, R.S., Song, J.J., Celeste, A.J., Melton, D.A. Cell (1994) [Pubmed]
  2. Dorsal-ventral patterning and neural induction in Xenopus embryos. De Robertis, E.M., Kuroda, H. Annu. Rev. Cell Dev. Biol. (2004) [Pubmed]
  3. Involvement of the small GTPases XRhoA and XRnd1 in cell adhesion and head formation in early Xenopus development. Wünnenberg-Stapleton, K., Blitz, I.L., Hashimoto, C., Cho, K.W. Development (1999) [Pubmed]
  4. Animal-vegetal asymmetries influence the earliest steps in retina fate commitment in Xenopus. Moore, K.B., Moody, S.A. Dev. Biol. (1999) [Pubmed]
  5. Structural and functional analysis of the BMP-4 promoter in early embryos of Xenopus laevis. Metz, A., Knöchel, S., Büchler, P., Köster, M., Knöchel, W. Mech. Dev. (1998) [Pubmed]
  6. Xenopus Smad8 acts downstream of BMP-4 to modulate its activity during vertebrate embryonic patterning. Nakayama, T., Snyder, M.A., Grewal, S.S., Tsuneizumi, K., Tabata, T., Christian, J.L. Development (1998) [Pubmed]
  7. Identification of neural genes using Xenopus DNA microarrays. Shin, Y., Kitayama, A., Koide, T., Peiffer, D.A., Mochii, M., Liao, A., Ueno, N., Cho, K.W. Dev. Dyn. (2005) [Pubmed]
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