The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

LOC397711  -  BMP receptor

Xenopus laevis

 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on LOC397711

  • Expression of this truncated BMP receptor during embryogenesis converts ventral mesoderm to dorsal mesoderm [1].
  • Phosphorylation by BMP receptor stimulates Smad1 transcriptional activity, whereas phosphorylation by MAPK has the opposite effect [2].
  • When coinjected with dominant-negative BMP receptor (tBR) in the ventral side of the embryo, XRhoA causes the formation of head structures resembling the phenotype seen after coinjection of wnt inhibitors with dominant-negative BMP receptor [3].
  • Conversely, reducing BMP signaling by expression of a dominant-negative BMP receptor or Noggin allows other animal blastomeres to contribute to the retina [4].
  • Since reporter activity obtained with distinct BMP-2/4 responsive promoter deletion mutants is simultaneously inhibited by the dominant negative BMP receptor as well as by chordin, we suggest that down-regulation of the BMP-4 gene by chordin results from an interference with the auto-regulatory loop at the level of protein-protein interactions [5].
 

Anatomical context of LOC397711

 

Associations of LOC397711 with chemical compounds

  • BMP signaling is mediated by specific Smad proteins, Smad1 and/or Smad5, which undergo serine phosphorylation in response to BMP-receptor activation and are then translocated to the nucleus where they modulate transcription of target genes [6].
 

Analytical, diagnostic and therapeutic context of LOC397711

  • RNAs were isolated from control animal cap explants and from dominant-negative BMP receptor expressing animal caps and subjected to a microarray experiment using newly generated high-density Xenopus DNA microarray chips representing over 17,000 unigenes [7].

References

  1. Studies with a Xenopus BMP receptor suggest that ventral mesoderm-inducing signals override dorsal signals in vivo. Graff, J.M., Thies, R.S., Song, J.J., Celeste, A.J., Melton, D.A. Cell (1994) [Pubmed]
  2. Dorsal-ventral patterning and neural induction in Xenopus embryos. De Robertis, E.M., Kuroda, H. Annu. Rev. Cell Dev. Biol. (2004) [Pubmed]
  3. Involvement of the small GTPases XRhoA and XRnd1 in cell adhesion and head formation in early Xenopus development. Wünnenberg-Stapleton, K., Blitz, I.L., Hashimoto, C., Cho, K.W. Development (1999) [Pubmed]
  4. Animal-vegetal asymmetries influence the earliest steps in retina fate commitment in Xenopus. Moore, K.B., Moody, S.A. Dev. Biol. (1999) [Pubmed]
  5. Structural and functional analysis of the BMP-4 promoter in early embryos of Xenopus laevis. Metz, A., Knöchel, S., Büchler, P., Köster, M., Knöchel, W. Mech. Dev. (1998) [Pubmed]
  6. Xenopus Smad8 acts downstream of BMP-4 to modulate its activity during vertebrate embryonic patterning. Nakayama, T., Snyder, M.A., Grewal, S.S., Tsuneizumi, K., Tabata, T., Christian, J.L. Development (1998) [Pubmed]
  7. Identification of neural genes using Xenopus DNA microarrays. Shin, Y., Kitayama, A., Koide, T., Peiffer, D.A., Mochii, M., Liao, A., Ueno, N., Cho, K.W. Dev. Dyn. (2005) [Pubmed]
 
WikiGenes - Universities