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Gene Review:

cadA - CadA subunit of lysine decarboxylase

Escherichia coli UTI89

Ivey, D.M. et al., Merrell, D.S. et al., Kitagawa, W. et al., Zhang, W. et al.

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Disease relevance of cadA

A partial sequence of a region approximately 2 kb downstream of the cadA locus shares sequence similarity with plasmids from several gram-positive bacteria [1].
The plasmid, designated pJB22, contained two genes that apparently encode transposition functions and two genes that are apparent homologs of the cadA and cadC genes of cadmium resistance-conferring plasmid pI258 of Staphylococcus aureus [1].
Five 2,4-D degraders, including Bradyrhizobium and Sphingomonas strains, were found to have cadA gene homologs, suggesting that these 2,4-D degraders share 2,4-D degradation genes similar to those of strain HW13 cadABC [2].
Unlike in Escherichia coli, V. cholerae cadB and cadA are also transcribed monocistronically [3].

Associations of cadA with chemical compounds

Strains with fliC(H10) and fliC(H11), but not those with fliC(H8), retained intact cadA and cadC loci and decarboxylated lysine [4].

References

The cadC gene product of alkaliphilic Bacillus firmus OF4 partially restores Na+ resistance to an Escherichia coli strain lacking an Na+/H+ antiporter (NhaA). Ivey, D.M., Guffanti, A.A., Shen, Z., Kudyan, N., Krulwich, T.A. J. Bacteriol. (1992) [Pubmed]
Novel 2,4-dichlorophenoxyacetic acid degradation genes from oligotrophic Bradyrhizobium sp. strain HW13 isolated from a pristine environment. Kitagawa, W., Takami, S., Miyauchi, K., Masai, E., Kamagata, Y., Tiedje, J.M., Fukuda, M. J. Bacteriol. (2002) [Pubmed]
Regulation of vibrio cholerae genes required for acid tolerance by a member of the "ToxR-like" family of transcriptional regulators. Merrell, D.S., Camilli, A. J. Bacteriol. (2000) [Pubmed]
Structural and functional differences between disease-associated genes of enterohaemorrhagic Escherichia coli O111. Zhang, W., Mellmann, A., Sonntag, A.K., Wieler, L., Bielaszewska, M., Tschäpe, H., Karch, H., Friedrich, A.W. Int. J. Med. Microbiol. (2007) [Pubmed]

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