Disease relevance of uspA

• Induced expression of the heat shock protein genes uspA and grpE during starvation at low temperatures and their influence on thermal resistance of Escherichia coli O157:H7 [1].
• Role of the universal stress protein UspA of Salmonella in growth arrest, stress and virulence [2].

High impact information on uspA

• Inactivation of uspA in S. typhimurium C5, lead to increased susceptibility to stress conditions [2].
• An in silico screen of the Salmonella genome sequence revealed that Salmonella typhimurium LT2 possesses a homologue belonging to the universal stress protein A (UspA) family [2].
• Furthermore, UspA makes an important contribution to the in vivo virulence of Salmonella in mice thus highlighting the importance of stress resistance regulation in pathogenicity and survival within the host [2].

Analytical, diagnostic and therapeutic context of uspA

• These were then tested by multiplex PCR for E. coli uspA, bla(CMY) and the class 1 integron-associated dfrA17-aadA5 gene cassette for rapid identification of MDREC CG 1 (positive for all three genes) and CG 2 (positive for uspA and bla(CMY) only) [3].

References