Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

smug1 - single-strand-selective monofunctional...

Xenopus laevis

Wibley, J.E. et al., Haushalter, K.A. et al.

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High impact information on SMUG1

Ung knockout mice display no increase in mutation frequency due to a second UDG activity, SMUG1, which is specialized for antimutational uracil excision in mammalian cells [1].
This structure indicates a more invasive interaction with dsDNA than observed with other UDGs and reveals an elegant water displacement/replacement mechanism that allows SMUG1 to exclude thymine from its active site while accepting HmU [1].
The unusual preference of SMUG1 for single-stranded rather than double-stranded DNA suggests a unique biological function in ridding the genome of uracil residues, which are potent endogenous mutagens [2].

References

Structure and specificity of the vertebrate anti-mutator uracil-DNA glycosylase SMUG1. Wibley, J.E., Waters, T.R., Haushalter, K., Verdine, G.L., Pearl, L.H. Mol. Cell (2003) [Pubmed]
Identification of a new uracil-DNA glycosylase family by expression cloning using synthetic inhibitors. Haushalter, K.A., Todd Stukenberg, M.W., Kirschner, M.W., Verdine, G.L. Curr. Biol. (1999) [Pubmed]

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