Gene Review:
SMUG1 - single-strand-selective monofunctional...
Homo sapiens
Synonyms:
FDG, HMUDG, Single-strand selective monofunctional uracil DNA glycosylase, UNG3
- Base J, found in nuclear DNA of Trypanosoma brucei, is not a target for DNA glycosylases. Ulbert, S., Eide, L., Seeberg, E., Borst, P. DNA Repair (Amst.) (2004)
- Definitive identification of mammalian 5-hydroxymethyluracil DNA N-glycosylase activity as SMUG1. Boorstein, R.J., Cummings, A., Marenstein, D.R., Chan, M.K., Ma, Y., Neubert, T.A., Brown, S.M., Teebor, G.W. J. Biol. Chem. (2001)
- Assessment of axillary lymph node involvement in breast cancer patients with positron emission tomography using radiolabeled 2-(fluorine-18)-fluoro-2-deoxy-D-glucose. Avril, N., Dose, J., Jänicke, F., Ziegler, S., Römer, W., Weber, W., Herz, M., Nathrath, W., Graeff, H., Schwaiger, M. J. Natl. Cancer Inst. (1996)
- Axillary lymph node staging in breast cancer by 2-fluoro-2-deoxy-D-glucose-positron emission tomography: clinical evaluation and alternative management. Greco, M., Crippa, F., Agresti, R., Seregni, E., Gerali, A., Giovanazzi, R., Micheli, A., Asero, S., Ferraris, C., Gennaro, M., Bombardieri, E., Cascinelli, N. J. Natl. Cancer Inst. (2001)
- Profound underestimation of glucose uptake by [18F]2-deoxy-2-fluoroglucose in reperfused rat heart muscle. Doenst, T., Taegtmeyer, H. Circulation (1998)
- 2-18fluoro-deoxy-D-glucose positron emission tomography is a reliable predictor for viable tumor in postchemotherapy seminoma: an update of the prospective multicentric SEMPET trial. De Santis, M., Becherer, A., Bokemeyer, C., Stoiber, F., Oechsle, K., Sellner, F., Lang, A., Kletter, K., Dohmen, B.M., Dittrich, C., Pont, J. J. Clin. Oncol. (2004)
- Discrimination between Alzheimer dementia and controls by automated analysis of multicenter FDG PET. Herholz, K., Salmon, E., Perani, D., Baron, J.C., Holthoff, V., Frölich, L., Schönknecht, P., Ito, K., Mielke, R., Kalbe, E., Zündorf, G., Delbeuck, X., Pelati, O., Anchisi, D., Fazio, F., Kerrouche, N., Desgranges, B., Eustache, F., Beuthien-Baumann, B., Menzel, C., Schröder, J., Kato, T., Arahata, Y., Henze, M., Heiss, W.D. Neuroimage (2002)
- Striatal glucose metabolism and dopamine D2 receptor binding in asymptomatic gene carriers and patients with Huntington's disease. Antonini, A., Leenders, K.L., Spiegel, R., Meier, D., Vontobel, P., Weigell-Weber, M., Sanchez-Pernaute, R., de Yébenez, J.G., Boesiger, P., Weindl, A., Maguire, R.P. Brain (1996)
- Regional cerebral glucose metabolism in children with deterioration of one or more cognitive functions and continuous spike-and-wave discharges during sleep. Maquet, P., Hirsch, E., Metz-Lutz, M.N., Motte, J., Dive, D., Marescaux, C., Franck, G. Brain (1995)
- Uracil-DNA glycosylase acts by substrate autocatalysis. Dinner, A.R., Blackburn, G.M., Karplus, M. Nature (2001)
- B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil. Kavli, B., Andersen, S., Otterlei, M., Liabakk, N.B., Imai, K., Fischer, A., Durandy, A., Krokan, H.E., Slupphaug, G. J. Exp. Med. (2005)
- The effect of non-insulin-dependent diabetes mellitus and obesity on glucose transport and phosphorylation in skeletal muscle. Kelley, D.E., Mintun, M.A., Watkins, S.C., Simoneau, J.A., Jadali, F., Fredrickson, A., Beattie, J., Thériault, R. J. Clin. Invest. (1996)
- Noninvasive monitoring of tumor metabolism using fluorodeoxyglucose and positron emission tomography in colorectal cancer liver metastases: correlation with tumor response to fluorouracil. Findlay, M., Young, H., Cunningham, D., Iveson, A., Cronin, B., Hickish, T., Pratt, B., Husband, J., Flower, M., Ott, R. J. Clin. Oncol. (1996)
- Synthesis and evaluation of 18F-labeled choline as an oncologic tracer for positron emission tomography: initial findings in prostate cancer. DeGrado, T.R., Coleman, R.E., Wang, S., Baldwin, S.W., Orr, M.D., Robertson, C.N., Polascik, T.J., Price, D.T. Cancer Res. (2001)
- Divergent expression of regional metabolic topographies in Parkinson's disease and normal ageing. Moeller, J.R., Eidelberg, D. Brain (1997)
- Changes in regional brain (18)F-fluorodeoxyglucose uptake at hypoglycemia in type 1 diabetic men associated with hypoglycemia unawareness and counter-regulatory failure. Cranston, I., Reed, L.J., Marsden, P.K., Amiel, S.A. Diabetes (2001)
- hSMUG1 can functionally compensate for Ung1 in the yeast Saccharomyces cerevisiae. Elateri, I., Tinkelenberg, B.A., Hansbury, M., Caradonna, S., Muller-Weeks, S., Ladner, R.D. DNA Repair (Amst.) (2003)
- Excision of deaminated cytosine from the vertebrate genome: role of the SMUG1 uracil-DNA glycosylase. Nilsen, H., Haushalter, K.A., Robins, P., Barnes, D.E., Verdine, G.L., Lindahl, T. EMBO J. (2001)
- SMUG1 is able to excise uracil from immunoglobulin genes: insight into mutation versus repair. Di Noia, J.M., Rada, C., Neuberger, M.S. EMBO J. (2006)
- The transcription factor, NFI/CTF plays a positive regulatory role in expression of the hSMUG1 gene. Elateri, I., Muller-Weeks, S., Caradonna, S. DNA Repair (Amst.) (2003)
- Mammalian 5-formyluracil-DNA glycosylase. 2. Role of SMUG1 uracil-DNA glycosylase in repair of 5-formyluracil and other oxidized and deaminated base lesions. Masaoka, A., Matsubara, M., Hasegawa, R., Tanaka, T., Kurisu, S., Terato, H., Ohyama, Y., Karino, N., Matsuda, A., Ide, H. Biochemistry (2003)
- In vivo imaging of neuronal activation and plasticity in the rat brain by high resolution positron emission tomography (microPET). Kornblum, H.I., Araujo, D.M., Annala, A.J., Tatsukawa, K.J., Phelps, M.E., Cherry, S.R. Nat. Biotechnol. (2000)
- Regional left ventricular wall thickening. Relation to regional uptake of 18fluorodeoxyglucose and 201Tl in patients with chronic coronary artery disease and left ventricular dysfunction. Perrone-Filardi, P., Bacharach, S.L., Dilsizian, V., Maurea, S., Frank, J.A., Bonow, R.O. Circulation (1992)
- DNA glycosylase recognition and catalysis. Fromme, J.C., Banerjee, A., Verdine, G.L. Curr. Opin. Struct. Biol. (2004)
- Mutational analysis of the damage-recognition and catalytic mechanism of human SMUG1 DNA glycosylase. Matsubara, M., Tanaka, T., Terato, H., Ohmae, E., Izumi, S., Katayanagi, K., Ide, H. Nucleic Acids Res. (2004)
- Myocardial blood flow, glucose uptake, and recruitment of inotropic reserve in chronic left ventricular ischemic dysfunction. Implications for the pathophysiology of chronic myocardial hibernation. Gerber, B.L., Vanoverschelde, J.L., Bol, A., Michel, C., Labar, D., Wijns, W., Melin, J.A. Circulation (1996)
- Metabolic responses of hibernating and infarcted myocardium to revascularization. A follow-up study of regional perfusion, function, and metabolism. Marwick, T.H., MacIntyre, W.J., Lafont, A., Nemec, J.J., Salcedo, E.E. Circulation (1992)