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Gene Review:

speE - spermidine synthase

Escherichia coli UTI89

Zappia, V. et al., Hashimoto, T. et al., Liu, C. et al., Kaiser, A.E. et al., Paulin, L. et al.

Kaiser, Gottwald, Wiersch, Maier, Seitz,

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Disease relevance of speE

Spermidine synthase (EC 2.5.1.16) purified from Escherichia coli has been subjected to a kinetic analysis including initial velocity and substrate analogs inhibition studies [1].

High impact information on speE

Mechanism of propylamine-transfer reactions. Kinetic and inhibition studies on spermidine synthase from Escherichia coli [1].
Two diastereomers of the potent spermidine synthase inhibitor S-adenosyl-1,8-diamino-3-thiooctane have been prepared in high (greater than 96% de) stereochemical purity [2].
Four cDNAs for spermidine synthase (SPDS), which converts the diamine putrescine to the higher polyamine spermidine using decarboxylated S-adenosylmethionine as the co-factor, were isolated from Nicotiana sylvestris, Hyoscyamus niger, and Arabidopsis thaliana [3].
Dicyclohexylammonium sulphate inhibited both spermidine synthase and spermine synthase activities in Acetobacteria [4].
Spermidine biosynthesis is catalyzed by spermidine synthase (EC 2.5.1.16) which transfers an aminopropyl moiety from decarboxylated S-adenosylmethionine to putrescine [5].

References

Mechanism of propylamine-transfer reactions. Kinetic and inhibition studies on spermidine synthase from Escherichia coli. Zappia, V., Cacciapuoti, G., Pontoni, G., Oliva, A. J. Biol. Chem. (1980) [Pubmed]
Stereospecific synthesis of (R)- and (S)-S-adenosyl-1,8-diamino-3-thiooctane, a potent inhibitor of polyamine biosynthesis. Comparison of asymmetric induction vs enantiomeric synthesis. Liu, C., Coward, J.K. J. Med. Chem. (1991) [Pubmed]
Molecular cloning of plant spermidine synthases. Hashimoto, T., Tamaki, K., Suzuki, K., Yamada, Y. Plant Cell Physiol. (1998) [Pubmed]
GTP-insensitive ornithine decarboxylase in acetobacteria able to synthesize spermine. Paulin, L., Vehmaanperä, J., Nykänen, I., Pösö, H. Biochem. Biophys. Res. Commun. (1983) [Pubmed]
Spermidine metabolism in parasitic protozoa--a comparison to the situation in prokaryotes, viruses, plants and fungi. Kaiser, A.E., Gottwald, A.M., Wiersch, C.S., Maier, W.A., Seitz, H.M. Folia Parasitol. (2003) [Pubmed]

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