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Gene Review

speE  -  spermidine synthase

Escherichia coli UTI89

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Disease relevance of speE

  • Spermidine synthase (EC purified from Escherichia coli has been subjected to a kinetic analysis including initial velocity and substrate analogs inhibition studies [1].

High impact information on speE


  1. Mechanism of propylamine-transfer reactions. Kinetic and inhibition studies on spermidine synthase from Escherichia coli. Zappia, V., Cacciapuoti, G., Pontoni, G., Oliva, A. J. Biol. Chem. (1980) [Pubmed]
  2. Stereospecific synthesis of (R)- and (S)-S-adenosyl-1,8-diamino-3-thiooctane, a potent inhibitor of polyamine biosynthesis. Comparison of asymmetric induction vs enantiomeric synthesis. Liu, C., Coward, J.K. J. Med. Chem. (1991) [Pubmed]
  3. Molecular cloning of plant spermidine synthases. Hashimoto, T., Tamaki, K., Suzuki, K., Yamada, Y. Plant Cell Physiol. (1998) [Pubmed]
  4. GTP-insensitive ornithine decarboxylase in acetobacteria able to synthesize spermine. Paulin, L., Vehmaanperä, J., Nykänen, I., Pösö, H. Biochem. Biophys. Res. Commun. (1983) [Pubmed]
  5. Spermidine metabolism in parasitic protozoa--a comparison to the situation in prokaryotes, viruses, plants and fungi. Kaiser, A.E., Gottwald, A.M., Wiersch, C.S., Maier, W.A., Seitz, H.M. Folia Parasitol. (2003) [Pubmed]
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