High impact information on TLE4

• In transient transfection assays, the Xenopus Groucho homologue XGrg-4 inhibited activation of transcription of synthetic Tcf reporter genes [1].
• Here we report that the function of FoxD3 in mesoderm induction is dependent on the recruitment of transcriptional corepressors of the TLE/Groucho family [2].
• Groucho proteins act to repress transcriptional activation by beta-catenin-Tcf complexes, probably by interacting directly with Tcf transcription factors [3].
• The major nuclear transducers of Wnt signals are the Tcf/LEF family of transcription factors, which have binding sites for both the transcriptional co-repressor groucho, and the co-activator beta-catenin [4].
• Cloning and developmental expression of Xenopus cDNAs encoding the Enhancer of split groucho and related proteins [5].

Biological context of TLE4

• The amino acid sequence of Xenopus ESG1 protein had 61% identity to the full-length Drosophila groucho [5].

Anatomical context of TLE4

• This result indicates that transcriptional repression by the Groucho/TLE-Xtcf-3 complex is important for ventral diencephalon patterning [6].
• Co-repressor Groucho/Transducin-Like Enhancer of split (TLE) interacts with transcription factors that are expressed in the central nervous system (CNS), and regulates transcriptional activities [6].

References