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Gene Review:

frc - fringe connection

Drosophila melanogaster

Synonyms: CG3874, Dmel\CG3874, FRC, Frc, Protein fringe connection, ...

Yano, H. et al., Goto, S. et al., Selva, E.M. et al.

Goto, Taniguchi, Muraoka, Toyoda, Sado, Kawakita, Hayashi,

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High impact information on frc

Mutants in the frc gene exhibit phenotypes resembling wingless and Notch mutants [1].
We describe a new gene, fringe connection (frc), that encodes a nucleotide-sugar transporter that transfers UDP-glucuronic acid, UDP-N-acetylglucosamine and possibly UDP-xylose from the cytoplasm into the lumen of the endoplasmic reticulum/Golgi [2].
Here, we report the functions of a novel UDP-sugar transporter (UST74C, an alternative name for Fringe connection (Frc)) localized to the Golgi apparatus in cellular signalling of Drosophila [1].
Whereas the glycosylation and function of NOTCH are affected in imaginal disks of frc mutants, those of SPI and of GAG core proteins are not, even though FRC transports a broad range of glycosylation substrates, suggesting that Golgi units containing FRC and those containing SFL or RHO are functionally separable [3].

References

UDP-sugar transporter implicated in glycosylation and processing of Notch. Goto, S., Taniguchi, M., Muraoka, M., Toyoda, H., Sado, Y., Kawakita, M., Hayashi, S. Nat. Cell Biol. (2001) [Pubmed]
Dual role of the fringe connection gene in both heparan sulphate and fringe-dependent signalling events. Selva, E.M., Hong, K., Baeg, G.H., Beverley, S.M., Turco, S.J., Perrimon, N., Häcker, U. Nat. Cell Biol. (2001) [Pubmed]
Distinct functional units of the Golgi complex in Drosophila cells. Yano, H., Yamamoto-Hino, M., Abe, M., Kuwahara, R., Haraguchi, S., Kusaka, I., Awano, W., Kinoshita-Toyoda, A., Toyoda, H., Goto, S. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]

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