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Gene Review:

SLC35D1 - solute carrier family 35 (UDP-GlcA/UDP...

Homo sapiens

Synonyms: KIAA0260, Solute carrier family 35 member D1, UDP-GlcA/UDP-GalNAc transporter, UDP-galactose transporter-related protein 7, UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter, ...

Muraoka, M. et al., Ishida, N. et al., Kobayashi, T. et al.

Ishida, Kuba, Aoki, Miyatake, Kawakita, Sanai,

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High impact information on SLC35D1

SLC35D2 was localized in the Golgi membrane and exhibited around 50% similarity with three nucleotide sugar transporters: human SLC35D1 (UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter), fruitfly fringe connection (frc) transporter, and nematode SQV-7 transporter, the latter two being involved in developmental and organogenetic processes [1].
The strategy for the identification of the novel NST involved a search of the expressed sequence tags database for genes related to the human UDP-galactose transporter-related isozyme 1, followed by heterologous expression of a candidate gene (hUGTrel7) in Saccharomyces cerevisiae and biochemical analyses [2].
Significantly more UDP-GlcA and UDP-GalNAc were translocated from the reaction medium into the lumen of microsomes prepared from the hUGTrel7-expressing yeast cells than into the control microsomes from cells not expressing hUGTrel7 [2].
The highest uptake was seen with UGTrel7, which displayed a V(max) approx. 1% of rat liver microsomes [3].

References

Identification and characterization of human Golgi nucleotide sugar transporter SLC35D2, a novel member of the SLC35 nucleotide sugar transporter family. Ishida, N., Kuba, T., Aoki, K., Miyatake, S., Kawakita, M., Sanai, Y. Genomics (2005) [Pubmed]
Molecular characterization of human UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter, a novel nucleotide sugar transporter with dual substrate specificity. Muraoka, M., Kawakita, M., Ishida, N. FEBS Lett. (2001) [Pubmed]
Molecular and functional characterization of microsomal UDP-glucuronic acid uptake by members of the nucleotide sugar transporter (NST) family. Kobayashi, T., Sleeman, J.E., Coughtrie, M.W., Burchell, B. Biochem. J. (2006) [Pubmed]

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AgaP_AGAP005200	Anopheles gambiae str. PEST
AT4G32272	Arabidopsis thaliana
SLC35D1	Bos taurus
sqv-7	Caenorhabditis elegans
LOC100685241	Canis lupus familiaris
slc35d1a	Danio rerio
frc	Drosophila melanogaster
SLC35D1	Gallus gallus
SLC35D1	Macaca mulatta
Slc35d1	Mus musculus
Os02g0614100	Oryza sativa Japonica Group
SLC35D1	Pan troglodytes
Slc35d1	Rattus norvegicus
LOC100497699	Xenopus (Silurana) tropicalis

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