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Gene Review:

tbp-a - TATA box binding protein

Xenopus laevis

Synonyms: TBP, gtf2d, gtf2d1, sca17, tfiid, ...

Huber, P.W. et al., Neely, L.S. et al., Martianov, I. et al., Wolffe, A.P. et al., Hall, R.K. et al., et al.

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High impact information on TFIIDtau

Transcription factor IIIA interacts specifically with an internal control region of Xenopus 5S ribosomal RNA genes and is also a component, along with 5S rRNA, of a 7S ribonucleoprotein particle present in previtellogenic oocytes [1].
While TBP is ubiquitously expressed, TLF expression is strictly developmentally regulated, being very high in late pachytene spermatocytes, suggesting a function prior to the apoptosis of the haploid cells [2].
Transcription factor IIIA, the internal control region of the 5 S RNA gene and specific DNA sequences 5' and 3' of the internal control region are all involved in the formation of a multiprotein complex [3].
Point mutations 5' to the tRNA selenocysteine TATA box alter RNA polymerase III transcription by affecting the binding of TBP [4].
Transcription factor IIIA of Xenopuslaevis serves a dual function during oogenesis and early development: this zinc finger protein binds to the internal promoter element of the 5 S ribosomal RNA genes and acts as a positive transcription factor; additionally, the protein functions in 5 S RNA storage [5].

Biological context of TFIIDtau

Transcription factor IIIA gene expression in Xenopus oocytes utilizes a transcription factor similar to the major late transcription factor [6].

References

Identification of the binding site on 5S rRNA for the transcription factor IIIA: proposed structure of a common binding site on 5S rRNA and on the gene. Huber, P.W., Wool, I.G. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
Distinct functions of TBP and TLF/TRF2 during spermatogenesis: requirement of TLF for heterochromatic chromocenter formation in haploid round spermatids. Martianov, I., Brancorsini, S., Gansmuller, A., Parvinen, M., Davidson, I., Sassone-Corsi, P. Development (2002) [Pubmed]
The transcription complex of the Xenopus somatic 5 S RNA gene. A functional analysis of protein-DNA interactions outside of the internal control region. Wolffe, A.P., Morse, R.H. J. Biol. Chem. (1990) [Pubmed]
Point mutations 5' to the tRNA selenocysteine TATA box alter RNA polymerase III transcription by affecting the binding of TBP. Myslinski, E., Schuster, C., Huet, J., Sentenac, A., Krol, A., Carbon, P. Nucleic Acids Res. (1993) [Pubmed]
Identification of a minimal domain of 5 S ribosomal RNA sufficient for high affinity interactions with the RNA-specific zinc fingers of transcription factor IIIA. Neely, L.S., Lee, B.M., Xu, J., Wright, P.E., Gottesfeld, J.M. J. Mol. Biol. (1999) [Pubmed]
Transcription factor IIIA gene expression in Xenopus oocytes utilizes a transcription factor similar to the major late transcription factor. Hall, R.K., Taylor, W.L. Mol. Cell. Biol. (1989) [Pubmed]

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