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Gene Review:

MUT - methylmalonyl CoA mutase

Sus scrofa

Metz, J., Toyoshima, M. et al., Young, P.B. et al., Naranjo, V. et al., Kierstein, S. et al., et al.

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Disease relevance of MUT

The lesion was thought to arise primarily from impairment of the adenosylcobalamin-dependent methylmalonyl CoA mutase reaction, leading to the formation of abnormal odd-chain and branched-chain fatty acids and their incorporation into myelin with resultant demyelination [1].
Activity of the vitamin B12-dependent enzyme, methylmalonyl CoA mutase, was measured in the tissues of pigs, fed a diet which was low in cobalt and vitamin B12, and which were intermittently exposed to nitrous oxide until they displayed marked ataxia [2].

High impact information on MUT

The C3 and MUT genes, therefore, are likely to be good candidates to study as markers of bTB resistance using functional genomics in animal model systems [3].
A polymorphic microsatellite located within the second intron of the methylmalonyl-CoA mutase (MUT) gene on SSC 1 [4].
These results provide indirect evidence that in enterocytes methylmalonyl-CoA mutase, the coenzyme of which is Ado-Cbl, is located in the mitochondrial fraction and that methionine synthetase, the coenzyme of which is Me-Cbl, is located in the sap fraction [5].
Assignment of the methylmalonyl-CoA mutase gene (MUT) to porcine chromosome 7q13-->q14 by in situ hybridization and analysis of radiation hybrid panels [6].

References

Cobalamin deficiency and the pathogenesis of nervous system disease. Metz, J. Annu. Rev. Nutr. (1992) [Pubmed]
Effect of N2O treatment/vitamin B12 deficiency in pigs on tissue concentrations of odd-numbered, branched-chain fatty acids. Young, P.B., Kennedy, S., Molloy, A.M., Scott, J.M., Weir, D.G., Kennedy, D.G. International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition. (1995) [Pubmed]
Characterization of selected genes upregulated in non-tuberculous European wild boar as possible correlates of resistance to Mycobacterium bovis infection. Naranjo, V., Ayoubi, P., Vicente, J., Ruiz-Fons, F., Gortazar, C., Kocan, K.M., de la Fuente, J. Vet. Microbiol. (2006) [Pubmed]
A polymorphic microsatellite located within the second intron of the methylmalonyl-CoA mutase (MUT) gene on SSC 1. Duscher, S., Peters, U., Brenig, B. Anim. Genet. (2000) [Pubmed]
Cobalamin derivatives in subcellular fractions of porcine ileal enterocytes. Toyoshima, M., Gräsbeck, R. Scand. J. Clin. Lab. Invest. (1987) [Pubmed]
Assignment of the methylmalonyl-CoA mutase gene (MUT) to porcine chromosome 7q13-->q14 by in situ hybridization and analysis of radiation hybrid panels. Kierstein, S., Peters, U., Habermann, F.A., Fries, R., Brenig, B. Cytogenet. Genome Res. (2003) [Pubmed]

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