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Gene Review

TLR4  -  toll-like receptor 4

Sus scrofa

 
 
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Disease relevance of TLR4

 

High impact information on TLR4

  • Our results suggest that ecabet may suppress TLR4-mediated inflammation or accelerated apoptosis caused H. pylori infection [4].
  • Incubation of H. pylori LPS with ecabet eliminated the toxic effects of the LPS, and nondenatured polyacrylamide gel electrophoresis indicated the formation of higher molecular mass complexes between H. pylori LPS and ecabet, suggesting that ecabet may interact with H. pylori LPS and block the activation of Toll-like receptor 4 (TLR4) [4].
  • The type I interferon response of these MoDC to poly I:C (TLR3 ligand), LPS (TLR4 ligand) and CpG (TLR9 ligand) was tested [5].
  • Immunoblot analysis and immunofluorescence histochemistry with an anti-TLR4 antibody showed that gastric pit cells possessed significant amounts of TLR4 protein preferentially on the plasma membrane [3].

References

  1. Genomic structure, promoter analysis and expression of the porcine (Sus scrofa) TLR4 gene. Thomas, A.V., Broers, A.D., Vandegaart, H.F., Desmecht, D.J. Mol. Immunol. (2006) [Pubmed]
  2. Helicobacter pylori lipopolysaccharide induces apoptosis of cultured guinea pig gastric mucosal cells. Kawahara, T., Teshima, S., Kuwano, Y., Oka, A., Kishi, K., Rokutan, K. Am. J. Physiol. Gastrointest. Liver Physiol. (2001) [Pubmed]
  3. Toll-like receptor 4 regulates gastric pit cell responses to Helicobacter pylori infection. Kawahara, T., Kuwano, Y., Teshima-Kondo, S., Kawai, T., Nikawa, T., Kishi, K., Rokutan, K. J. Med. Invest. (2001) [Pubmed]
  4. Ecabet sodium inhibits Helicobacter pylori lipopolysaccharide-induced activation of NADPH oxidase 1 or apoptosis of guinea pig gastric mucosal cells. Kusumoto, K., Kawahara, T., Kuwano, Y., Teshima-Kondo, S., Morita, K., Kishi, K., Rokutan, K. Am. J. Physiol. Gastrointest. Liver Physiol. (2005) [Pubmed]
  5. IL-13 replaces IL-4 in development of monocyte derived dendritic cells (MoDC) of swine. Bautista, E.M., Nfon, C., Ferman, G.S., Golde, W.T. Vet. Immunol. Immunopathol. (2007) [Pubmed]
 
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